Inotropic effect of taurine in guinea-pig ventricular strips

At 0.9 mM CaCl2 taurine prevented the negative inotropic effect due to low calcium concentration in guinea-pig ventricular strips but not in rat strips. This taurine effect was dose-dependent. The presence (in the perfusion medium) of beta-alanine, an inhibitor of taurine transport, antagonized the...

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Bibliographic Details
Published in:	European journal of pharmacology Vol. 102; no. 3-4; p. 511
Main Authors:	Franconi, F, Stendardi, I, Matucci, R, Failli, P, Bennardini, F, Antonini, G, Giotti, A
Format:	Journal Article
Language:	English
Published:	Netherlands 20-07-1984
Subjects:	Alanine - pharmacology Animals Calcium - physiology Cimetidine - pharmacology Drug Interactions Guinea Pigs In Vitro Techniques Indomethacin - pharmacology Male Myocardial Contraction - drug effects Propranolol - pharmacology Taurine - pharmacology
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Summary:	At 0.9 mM CaCl2 taurine prevented the negative inotropic effect due to low calcium concentration in guinea-pig ventricular strips but not in rat strips. This taurine effect was dose-dependent. The presence (in the perfusion medium) of beta-alanine, an inhibitor of taurine transport, antagonized the effect of taurine suggesting that the action of taurine was correlated to its transport. Neither propranolol, cimetidine nor indomethacin affected the response to taurine in guinea-pig ventricular strips.
ISSN:	0014-2999
DOI:	10.1016/0014-2999(84)90572-7