Famotidine, the new antiulcero-genic agent, a potent ligand for metal ions

• Published in: Journal of inorganic biochemistry Vol. 48; no. 3; p. 233
• Main Authors: Kozłowski, H, Kowalik-Jankowska, T, Anouar, A, Decock, P, Spychala, J, Swiatek, J, Ganadu, M L
• Format: Journal Article
• Language: English
• Published: United States 15-11-1992
• Subjects: Anti-Ulcer Agents - chemistry; Copper - chemistry; Electron Spin Resonance Spectroscopy; Famotidine - chemistry; Hydrogen-Ion Concentration; Ligands; Molecular Structure; Nickel - chemistry; Polarography; Potentiometry; Spectrophotometry, Ultraviolet; Thermodynamics
• ISSN: 0162-0134
• DOI: 10.1016/0162-0134(92)84034-K

Potentiometric, polarographic, and spectroscopic results obtained for Cu2+ and Ni(2+)-famotidine systems clearly indicated that this anti-ulcerogenic drug is a very potent chelating agent able to coordinate cupric ion that was at pH below 2. This drug exhibits excellent histamine H2 receptor blocking effects and its effective coordination to metal ions may have significant biological implications. Famotidine is found to be a very effective ligand for Ni2+ ions also.