Effects of nandrolone decanoate in NZB/W mice treated concomitantly with maintenance doses of dexamethasone sodium phosphate

Treatment of female or castrated male NZB/W mice with nandrolone decanoate (80 mg/kg s.c.), once every three weeks, delays the onset of murine lupus and associated symptoms, even when treatment was started at the 17th week of age. Continuous low dose glucocorticoid therapy did not affect the therape...

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Bibliographic Details
Published in:	International journal of immunopharmacology Vol. 7; no. 2; p. 249
Main Authors:	Verheul, H A, Deckers, G H, Schuurs, A H
Format:	Journal Article
Language:	English
Published:	England 1985
Subjects:	Animals Body Weight - drug effects Castration Dexamethasone - administration & dosage Disease Models, Animal Female Lupus Erythematosus, Systemic - drug therapy Male Mice Mice, Inbred NZB Nandrolone - administration & dosage Nandrolone - analogs & derivatives Nandrolone Decanoate Proteinuria - chemically induced
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Summary:	Treatment of female or castrated male NZB/W mice with nandrolone decanoate (80 mg/kg s.c.), once every three weeks, delays the onset of murine lupus and associated symptoms, even when treatment was started at the 17th week of age. Continuous low dose glucocorticoid therapy did not affect the therapeutic effects of the nandrolone decanoate injections. These results indicate that SLE patients receiving maintenance low dose glucocorticoid therapy may also benefit from treatment with nandrolone-decanoate.
ISSN:	0192-0561
DOI:	10.1016/0192-0561(85)90033-5