Type-II thyroxine 5'-deiodinase is present in the rat pineal gland

Thyroxine-5'-deiodinase has been identified in the rat pineal gland. The characteristics of the enzyme are compatible with a Type-II deiodinase which is tissue-specific and presumably related to generating a local action of thyroid hormone. Our data suggest there may be a previously unrecognize...

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Bibliographic Details
Published in:	Biochemical and biophysical research communications Vol. 137; no. 2; p. 863
Main Authors:	Tanaka, K, Murakami, M, Greer, M A
Format:	Journal Article
Language:	English
Published:	United States 13-06-1986
Subjects:	Animals Female Hypothyroidism - enzymology Iodide Peroxidase - antagonists & inhibitors Iodide Peroxidase - metabolism Iodides - analysis Isoenzymes - antagonists & inhibitors Isoenzymes - metabolism Kinetics Pineal Gland - enzymology Rats Rats, Inbred Strains Substrate Specificity
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Summary:	Thyroxine-5'-deiodinase has been identified in the rat pineal gland. The characteristics of the enzyme are compatible with a Type-II deiodinase which is tissue-specific and presumably related to generating a local action of thyroid hormone. Our data suggest there may be a previously unrecognized role of thyroid hormone in the regulation of pineal activity.
ISSN:	0006-291X
DOI:	10.1016/0006-291X(86)91159-9