Changes in cerebrospinal fluid Na+ concentration do not underlie hypertensive responses to dietary NaCl in spontaneously hypertensive rats

• Published in: Brain research Vol. 506; no. 1; p. 149
• Main Authors: Mozaffari, M S, Jirakulsomchok, S, Oparil, S, Wyss, J M
• Format: Journal Article
• Language: English
• Published: Netherlands 01-01-1990
• Subjects: Animals; Rats; Rats, Inbred SHR - metabolism; Rats, Inbred Strains - metabolism; Sodium - blood; Sodium - cerebrospinal fluid; Sodium, Dietary - pharmacokinetics
• ISSN: 0006-8993
• DOI: 10.1016/0006-8993(90)91212-Y

This study tests the hypothesis that dietary NaCl loading increases cerebrospinal fluid (CSF) Na+ concentration in NaCl-sensitive spontaneously hypertensive rats (SHR-S), resulting in an increase in arterial pressure. The high NaCl diet caused a significant rise in systolic arterial pressure in SHR-S but not in normotensive Wistar Kyoto (WKY) rats. In contrast, the high NaCl diet caused a transient rise in CSF Na+ that was similar in amplitude in SHR-S and WKY. A second experiment demonstrated that in SHR-S, concomitant dietary Ca2+ supplementation attenuated the dietary NaCl-induced exacerbation of hypertension, but did not alter the transient increase in CSF Na+ concentration. Together, these results indicate that alterations in CSF Na+ concentration do not contribute to the increase in arterial pressure induced by a high NaCl diet in SHR-S.