The structure of mytilan, a bioglycan-immunomodulator isolated from the mussel Crenomytilus grayanus

Mytilan, isolated from the mantle of the mussel Crenomytilus grayanus and which possesses high immunomodulating activity, is a non-covalently linked complex of a polysaccharide (95%) and protein (5%) with lectin activities. Chromatography of mytilan on agarose separated the polysaccharide and protei...

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Bibliographic Details
Published in:	Carbohydrate research Vol. 223; p. 221
Main Authors:	Ovodova, R G, Glazkova, V E, Mikheyskaya, L V, Molchanova, V I, Isakov, V V, Ovodov, Y S, Fernandez Molina, L E
Format:	Journal Article
Language:	English
Published:	Netherlands 01-01-1992
Subjects:	Adjuvants, Immunologic alpha-Amylases Animals Bivalvia - chemistry Carbohydrate Conformation Carbohydrate Sequence Chromatography, Affinity Chromatography, Gel Methylation Molecular Sequence Data Molecular Weight Optical Rotation Polysaccharides - chemistry Polysaccharides - isolation & purification
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Summary:	Mytilan, isolated from the mantle of the mussel Crenomytilus grayanus and which possesses high immunomodulating activity, is a non-covalently linked complex of a polysaccharide (95%) and protein (5%) with lectin activities. Chromatography of mytilan on agarose separated the polysaccharide and protein constituents. The protein appeared to have the lectin properties. Methylation analysis, Smith degradation, digestion with alpha-amylase, and 13C-n.m.r. spectroscopy showed the polysaccharide to be a glycogen-like alpha-D-glucan.
ISSN:	0008-6215
DOI:	10.1016/0008-6215(92)80018-V