Circadian disruption induced by light-at-night accelerates aging and promotes tumorigenesis in young but not in old rats
We evaluated the effect of exposure to constant light started at the age of 1 month and at the age of 14 months on the survival, life span, tumorigenesis and age-related dynamics of antioxidant enzymes activity in various organs in comparison to the rats maintained at the standard (12:12 light/dark)...
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| Published in: | Aging (Albany, NY.) Vol. 2; no. 2; pp. 82 - 92 |
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| Main Authors: | , , , , , , , |
| Format: | Journal Article |
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| Abstract | We evaluated the effect of exposure to constant light started at the age of 1 month and at the age of 14 months on the survival, life span, tumorigenesis and age-related dynamics of antioxidant enzymes activity in various organs in comparison to the rats maintained at the standard (12:12 light/dark) light/dark regimen. We found that exposure to constant light started at the age of 1 month accelerated spontaneous tumorigenesis and shortened life span both in male and female rats as compared to the standard regimen. At the same time, the exposure to constant light started at the age of 14 months failed to influence survival of male and female rats. While delaying tumors in males, constant light accelerated tumors in females. We conclude that circadian disruption induced by light-at-night started at the age of 1 month accelerates aging and promotes tumorigenesis in rats, however failed affect survival when started at the age of 14 months. |
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| AbstractList | We evaluated
the effect of exposure to constant light started at the age of 1 month and
at the age of 14 months on the survival, life span, tumorigenesis and
age-related dynamics of antioxidant enzymes activity in various organs in
comparison to the rats maintained at the standard (12:12 light/dark)
light/dark regimen. We found that exposure to constant light started at the
age of 1 month accelerated spontaneous tumorigenesis and shortened life
span both in male and female rats as compared to the standard regimen. At
the same time, the exposure to constant light started at the age of 14
months failed to influence survival of male and female rats. While delaying
tumors in males, constant light accelerated tumors in females. We conclude
that circadian disruption induced by light-at-night started at the age of 1
month accelerates aging and promotes tumorigenesis in rats, however failed
affect survival when started at the age of 14 months. We evaluated the effect of exposure to constant light started at the age of 1 month and at the age of 14 months on the survival, life span, tumorigenesis and age-related dynamics of antioxidant enzymes activity in various organs in comparison to the rats maintained at the standard (12:12 light/dark) light/dark regimen. We found that exposure to constant light started at the age of 1 month accelerated spontaneous tumorigenesis and shortened life span both in male and female rats as compared to the standard regimen. At the same time, the exposure to constant light started at the age of 14 months failed to influence survival of male and female rats. While delaying tumors in males, constant light accelerated tumors in females. We conclude that circadian disruption induced by light-at-night started at the age of 1 month accelerates aging and promotes tumorigenesis in rats, however failed affect survival when started at the age of 14 months. |
| Author | Anisimov, Vladimir N Bukalev, Andrey V Vinogradova, Irina A Lotosh, Tatiana A Semenchenko, Anna V Ilyukha, Viktor A Zabezhinski, Mark A Khizhkin, Evgeniy A |
| AuthorAffiliation | 2 Department of Carcinogenesis and Oncogerontology, N.N.Petrov Research Institute of Oncology, St. Petersburg 197758, Russia 3 Institute of Biology, Karelian Research Centre, Russian Academy of Sciences, Petrozavodsk 185610; Russia 1 Petrozavodsk State University, Petrozavodsk 185910, Russia |
| AuthorAffiliation_xml | – name: 2 Department of Carcinogenesis and Oncogerontology, N.N.Petrov Research Institute of Oncology, St. Petersburg 197758, Russia – name: 3 Institute of Biology, Karelian Research Centre, Russian Academy of Sciences, Petrozavodsk 185610; Russia – name: 1 Petrozavodsk State University, Petrozavodsk 185910, Russia |
| Author_xml | – sequence: 1 givenname: Irina A surname: Vinogradova fullname: Vinogradova, Irina A email: aging@mail.ru organization: Petrozavodsk State University, Petrozavodsk 185910, Russia. aging@mail.ru – sequence: 2 givenname: Vladimir N surname: Anisimov fullname: Anisimov, Vladimir N – sequence: 3 givenname: Andrey V surname: Bukalev fullname: Bukalev, Andrey V – sequence: 4 givenname: Viktor A surname: Ilyukha fullname: Ilyukha, Viktor A – sequence: 5 givenname: Evgeniy A surname: Khizhkin fullname: Khizhkin, Evgeniy A – sequence: 6 givenname: Tatiana A surname: Lotosh fullname: Lotosh, Tatiana A – sequence: 7 givenname: Anna V surname: Semenchenko fullname: Semenchenko, Anna V – sequence: 8 givenname: Mark A surname: Zabezhinski fullname: Zabezhinski, Mark A |
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| Cites_doi | 10.1093/occmed/kqg048 10.1016/j.mad.2008.02.004 10.1093/ije/dyp178 10.1177/107327480701400104 10.1007/s10552-005-9001-x 10.1016/S1470-2045(07)70373-X 10.1097/01.ede.0000152525.21924.54 |
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| SubjectTerms | Age Factors Aging - radiation effects Animals Catalase - metabolism Circadian Rhythm - radiation effects Female Light - adverse effects Longevity - radiation effects Male Neoplasms - etiology Oxidative Stress - radiation effects Photoperiod Pineal Gland - radiation effects Rats Superoxide Dismutase - metabolism |
| Title | Circadian disruption induced by light-at-night accelerates aging and promotes tumorigenesis in young but not in old rats |
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