Mouse brain synaptosomal sodium channels: activation by aconitine, batrachotoxin, and veratridine, and inhibition by tetrodotoxin

Batrachotoxin, veratridine and aconitine, activators of the voltage-dependent sodium channel in excitable cell membranes, increase the rate of 22Na+ uptake by mouse brain synaptosomes. Batrachotoxin was both the most potent (K0.5, 0.49 microM) and most effective activator of specific 22Na+ uptake. V...

Full description

Bibliographic Details

Published in:	Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology Vol. 77; no. 2; p. 267
Main Authors:	Ghiasuddin, S M, Soderlund, D M
Format:	Journal Article
Language:	English
Published:	England 1984
Subjects:	Aconitine - pharmacology Animals Batrachotoxins - pharmacology Brain - metabolism In Vitro Techniques Ion Channels - drug effects Kinetics Male Mice Mice, Inbred ICR Sodium - metabolism Synaptosomes - metabolism Tetrodotoxin - pharmacology Veratridine - pharmacology
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!