Increasing the Complexity of Periodic Protein Nanostructures by the Rolling-Circle-Amplified Synthesis of Aptamers

The biomachinery of rolling‐circle amplification relying on protein–aptamer interactions on DNA scaffolds was used to create one‐dimensional DNA–protein/DNA–protein–nanoparticle hierarchical assemblies. These conjugates can serve as further templates for the immobilization of gold nanoparticles....

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Bibliographic Details
Published in:	Angewandte Chemie (International ed.) Vol. 47; no. 1; pp. 126 - 130
Main Authors:	Cheglakov, Zoya, Weizmann, Yossi, Braunschweig, Adam B, Wilner, Ofer I, Willner, Itamar
Format:	Journal Article
Language:	English
Published:	Weinheim Wiley-VCH Verlag 2008 WILEY-VCH Verlag WILEY‐VCH Verlag
Subjects:	aptamers Aptamers, Nucleotide - chemical synthesis Aptamers, Nucleotide - chemistry DNA DNA, Circular - chemistry DNA, Single-Stranded - chemistry Muramidase - chemistry nanoparticles Nanoparticles - chemistry nanostructures Nucleic Acid Amplification Techniques self-assembly Thrombin - chemistry
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Summary:	The biomachinery of rolling‐circle amplification relying on protein–aptamer interactions on DNA scaffolds was used to create one‐dimensional DNA–protein/DNA–protein–nanoparticle hierarchical assemblies. These conjugates can serve as further templates for the immobilization of gold nanoparticles.
Bibliography:	http://dx.doi.org/10.1002/anie.200703688 Y.W. is grateful to The Johanna Friedlander Memorial Fund for a fellowship. ark:/67375/WNG-V04C79V6-M ArticleID:ANIE200703688 istex:C90A382F46D3F3D515A96F3BC89EC8E493071949 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.200703688