Specific association of increased vascular endothelial growth factor expression and its receptors with macrophage differentiation of HL-60 leukemia cells

We investigated the gene expression profiles of vascular endothelial growth factor (VEGF) and its receptors in HL-60 leukemia cells. In the VEGF family, both mRNA and protein expression of VEGF-C were up-regulated in phorbol myristate acetate (PMA)-differentiated HL-60 cells. We detected two bands o...

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Published in:	Biochemical and biophysical research communications Vol. 368; no. 3; pp. 543 - 549
Main Authors:	Ohsaka, Akimichi, Hirota-Komatsu, Satoko, Shibata, Miki, Ezaki, Junji, Shinohara, Fumikazu, Yoshida, Tetsuo
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 11-04-2008
Subjects:	Cell Differentiation HL-60 HL-60 Cells Humans Macrophage differentiation Macrophages - cytology Macrophages - metabolism Receptors, Vascular Endothelial Growth Factor - metabolism Tumor angiogenesis Up-Regulation Vascular Endothelial Growth Factor A - metabolism Vascular Endothelial Growth Factor C - metabolism VEGF receptors VEGF-C Tumor angiogenesis VEGF-C HL-60 Macrophage differentiation VEGF receptors
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Abstract	We investigated the gene expression profiles of vascular endothelial growth factor (VEGF) and its receptors in HL-60 leukemia cells. In the VEGF family, both mRNA and protein expression of VEGF-C were up-regulated in phorbol myristate acetate (PMA)-differentiated HL-60 cells. We detected two bands of ∼31 and ∼60kDa in cell lysates, and the higher expression of ∼31kDa band was further increased after stimulation with tumor necrosis factor (TNF)-α and lipopolysaccharide (LPS). A ∼31kDa VEGF-C protein was also detected in conditioned media from PMA-differentiated HL-60 cells after LPS stimulation. The mRNA expression of VEGFR-1, VEGFR-2, and neuropilin-1 (NRP-1) was markedly up-regulated in PMA-differentiated HL-60 cells, corresponding to the results from VEGF binding studies, in which VEGF binding activity was increased in PMA-differentiated HL-60 cells. These did not occur in dimethylsulfoxide (DMSO)-differentiated HL-60 cells. The expression of VEGF-C and VEGF receptors is regulated specifically in HL-60 cells during macrophage differentiation.
AbstractList	We investigated the gene expression profiles of vascular endothelial growth factor (VEGF) and its receptors in HL-60 leukemia cells. In the VEGF family, both mRNA and protein expression of VEGF-C were up-regulated in phorbol myristate acetate (PMA)-differentiated HL-60 cells. We detected two bands of ∼31 and ∼60kDa in cell lysates, and the higher expression of ∼31kDa band was further increased after stimulation with tumor necrosis factor (TNF)-α and lipopolysaccharide (LPS). A ∼31kDa VEGF-C protein was also detected in conditioned media from PMA-differentiated HL-60 cells after LPS stimulation. The mRNA expression of VEGFR-1, VEGFR-2, and neuropilin-1 (NRP-1) was markedly up-regulated in PMA-differentiated HL-60 cells, corresponding to the results from VEGF binding studies, in which VEGF binding activity was increased in PMA-differentiated HL-60 cells. These did not occur in dimethylsulfoxide (DMSO)-differentiated HL-60 cells. The expression of VEGF-C and VEGF receptors is regulated specifically in HL-60 cells during macrophage differentiation. We investigated the gene expression profiles of vascular endothelial growth factor (VEGF) and its receptors in HL-60 leukemia cells. In the VEGF family, both mRNA and protein expression of VEGF-C were up-regulated in phorbol myristate acetate (PMA)-differentiated HL-60 cells. We detected two bands of approximately 31 and approximately 60kDa in cell lysates, and the higher expression of approximately 31kDa band was further increased after stimulation with tumor necrosis factor (TNF)-alpha and lipopolysaccharide (LPS). A approximately 31kDa VEGF-C protein was also detected in conditioned media from PMA-differentiated HL-60 cells after LPS stimulation. The mRNA expression of VEGFR-1, VEGFR-2, and neuropilin-1 (NRP-1) was markedly up-regulated in PMA-differentiated HL-60 cells, corresponding to the results from VEGF binding studies, in which VEGF binding activity was increased in PMA-differentiated HL-60 cells. These did not occur in dimethylsulfoxide (DMSO)-differentiated HL-60 cells. The expression of VEGF-C and VEGF receptors is regulated specifically in HL-60 cells during macrophage differentiation. We investigated the gene expression profiles of vascular endothelial growth factor (VEGF) and its receptors in HL-60 leukemia cells. In the VEGF family, both mRNA and protein expression of VEGF-C were up-regulated in phorbol myristate acetate (PMA)-differentiated HL-60 cells. We detected two bands of ~31 and ~60kDa in cell lysates, and the higher expression of ~31kDa band was further increased after stimulation with tumor necrosis factor (TNF)- alpha and lipopolysaccharide (LPS). A ~31kDa VEGF-C protein was also detected in conditioned media from PMA-differentiated HL-60 cells after LPS stimulation. The mRNA expression of VEGFR-1, VEGFR-2, and neuropilin-1 (NRP-1) was markedly up-regulated in PMA-differentiated HL-60 cells, corresponding to the results from VEGF binding studies, in which VEGF binding activity was increased in PMA-differentiated HL-60 cells. These did not occur in dimethylsulfoxide (DMSO)-differentiated HL-60 cells. The expression of VEGF-C and VEGF receptors is regulated specifically in HL-60 cells during macrophage differentiation.
Author	Ohsaka, Akimichi Ezaki, Junji Yoshida, Tetsuo Shibata, Miki Shinohara, Fumikazu Hirota-Komatsu, Satoko
Author_xml	– sequence: 1 givenname: Akimichi surname: Ohsaka fullname: Ohsaka, Akimichi email: ohsaka@med.juntendo.ac.jp organization: Department of Transfusion Medicine and Stem Cell Regulation, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan – sequence: 2 givenname: Satoko surname: Hirota-Komatsu fullname: Hirota-Komatsu, Satoko organization: Department of Transfusion Medicine and Stem Cell Regulation, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan – sequence: 3 givenname: Miki surname: Shibata fullname: Shibata, Miki organization: Department of Transfusion Medicine and Stem Cell Regulation, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan – sequence: 4 givenname: Junji surname: Ezaki fullname: Ezaki, Junji organization: Department of Biochemistry, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, Japan – sequence: 5 givenname: Fumikazu surname: Shinohara fullname: Shinohara, Fumikazu organization: BioFrontier Laboratories, Kyowa Hakko Kogyo Co., Ltd., 3-6-6 Asahi-machi, Machida, Tokyo 194-8533, Japan – sequence: 6 givenname: Tetsuo surname: Yoshida fullname: Yoshida, Tetsuo organization: BioFrontier Laboratories, Kyowa Hakko Kogyo Co., Ltd., 3-6-6 Asahi-machi, Machida, Tokyo 194-8533, Japan
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/18261985$$D View this record in MEDLINE/PubMed
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Snippet	We investigated the gene expression profiles of vascular endothelial growth factor (VEGF) and its receptors in HL-60 leukemia cells. In the VEGF family, both...
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SubjectTerms	Cell Differentiation HL-60 HL-60 Cells Humans Macrophage differentiation Macrophages - cytology Macrophages - metabolism Receptors, Vascular Endothelial Growth Factor - metabolism Tumor angiogenesis Up-Regulation Vascular Endothelial Growth Factor A - metabolism Vascular Endothelial Growth Factor C - metabolism VEGF receptors VEGF-C
Title	Specific association of increased vascular endothelial growth factor expression and its receptors with macrophage differentiation of HL-60 leukemia cells
URI	https://dx.doi.org/10.1016/j.bbrc.2008.01.129 https://www.ncbi.nlm.nih.gov/pubmed/18261985 https://search.proquest.com/docview/20600359 https://search.proquest.com/docview/70355096
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