SP1 AND SP3 REGULATE BASAL TRANSCRIPTION OF THE HUMAN CYP2F1 GENE

Selective transcription of the human CYP2F1 gene in lung tissues may control the susceptibilities of this organ to diverse pneumotoxicants and lung carcinogens. However, the mechanisms responsible for CYP2F1 organ-selective transcription have not been elucidated. The objectives of the current studie...

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Bibliographic Details
Published in:	Drug metabolism and disposition Vol. 33; no. 8; pp. 1244 - 1253
Main Authors:	JIE WAN, CARR, Brian A, CUTLER, N. Shane, LANZA, Diane L, HINES, Ronald N, YOST, Garold S
Format:	Journal Article
Language:	English
Published:	Bethesda, MD American Society for Pharmacology and Experimental Therapeutics 01-08-2005
Subjects:	Base Sequence Binding Sites - genetics Biological and medical sciences Cell Line, Tumor Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism Cytochrome P450 Family 2 DNA - chemistry DNA - metabolism Drosophila Gene Expression Regulation Genes, Reporter Humans Luciferases - genetics Lung Medical sciences Molecular Sequence Data Pharmacology. Drug treatments Promoter Regions, Genetic Repressor Proteins Sp1 Transcription Factor - genetics Sp1 Transcription Factor - metabolism Sp3 Transcription Factor - genetics Sp3 Transcription Factor - metabolism Transcription, Genetic Transcriptional Activation Transfection Human Regulation(control) Gene Transcription
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