Bilirubin derived from heme degradation suppresses MHC class II expression in endothelial cells

The enzymatic action of heme oxygenase (HO) is mediated by the cleavage of heme into carbon monoxide, ferrous iron, and biliverdin/bilirubin. Here, we show that induction of HO-1 expression, an inducible form of HO, down-regulates IFN-γ-induced MHC class II expression in endothelial cells. Among thr...

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Bibliographic Details
Published in:	Biochemical and biophysical research communications Vol. 338; no. 2; pp. 890 - 896
Main Authors:	Wu, Jian, Ma, Jian, Fan, Sheung-Tat, Schlitt, Hans J., Tsui, Tung-Yu
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 16-12-2005
Subjects:	Animals Bilirubin Bilirubin - administration & dosage Bilirubin - chemistry Biodegradation, Environmental Cell Line Endothelial cells Epithelial Cells - drug effects Epithelial Cells - metabolism Gene Expression Regulation - drug effects Gene Expression Regulation - physiology Heme - chemistry Heme oxygenase-1 Heme Oxygenase-1 - metabolism Histocompatibility Antigens Class II - metabolism Interferon-gamma - administration & dosage Interferon-γ Major histocompatibility complex class II Membrane Proteins - metabolism Mice Bilirubin Interferon-γ Major histocompatibility complex class II Endothelial cells Heme oxygenase-1
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