$A Phase I Study of 5-Fluorouracil/Leucovorin and Arsenic Trioxide for Patients with Refractory/Relapsed Colorectal Carcinoma$
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A Phase I Study of 5-Fluorouracil/Leucovorin and Arsenic Trioxide for Patients with Refractory/Relapsed Colorectal Carcinoma

This Phase I study was designed to determine a safe combination dose of 5-fluorouracil (5-FU) and arsenic trioxide (ATO) to treat 5-FU-resistant relapsed/refractory colorectal cancer patients. We studied the effect of ATO in the downregulation of thymidylate synthase (TS) in peripheral blood mononuc...

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Bibliographic Details
Published in:	Clinical cancer research Vol. 16; no. 11; pp. 3019 - 3027
Main Authors:	ARDALAN, Bach, SUBBARAYAN, Pochi R, LIMA, Mayra, GANJEI-AZAR, Parvin, RAMOS, Yipsel, GONZALEZ, Michael, FERNANDEZ, Anthony, MEZENTSEV, Dmitry, REIS, Isildinha, DUNCAN, Robert, PODOLSKY, Lisa, LEE, Kelvin
Format:	Journal Article
Language:	English
Published:	Philadelphia, PA American Association for Cancer Research 01-06-2010
Subjects:	Adult Aged Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Arsenicals - administration & dosage Arsenicals - adverse effects Biological and medical sciences Colorectal Neoplasms - drug therapy Disease-Free Survival Drug Resistance, Neoplasm Female Fluorouracil - administration & dosage Gastroenterology. Liver. Pancreas. Abdomen Humans Leucovorin - administration & dosage Male Medical sciences Middle Aged Oxides - administration & dosage Oxides - adverse effects Pharmacology. Drug treatments Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Thymidylate Synthase - metabolism Tumors Antineoplastic agent Relapse Rectal disease Colorectal carcinoma Colorectal cancer Calcium folinate Intestinal disease Fluorouracil Human Treatment resistance Enzyme Fluoropyrimidine derivatives Transferases Enzyme inhibitor Patient Arsenic trioxide Malignant tumor Thymidylate synthase Colonic disease Treatment Antimetabolic Methyltransferases Phase I trial Pyrimidine derivatives Digestive diseases Cancer
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