T2-hyperintensity in the internal globus pallidus in Machado-Joseph disease

A 69-year-old male patient with Machado-Joseph disease (MJD) presented with mild cerebellar ataxia, global areflexia, and nystagmus. MRI showed cerebellar and brainstem atrophy, as well as abnormal hyperintensity along the medial aspect of the globus pallidus intemus. This finding suggests degenerat...

Full description

Saved in:

Bibliographic Details
Published in:	Arquivos de neuro-psiquiatria Vol. 81; no. 11; pp. 1018 - 1019
Main Authors:	Meira, Alex T., Araruna, Jorge E. D., Araujo, Lais Vieira, Leite, Raíssa N. L. F., Franklin, Gustavo L., Nepomuceno, Adriana M. T., Teive, Hélio A. G.
Format:	Journal Article
Language:	English
Published:	Sao Paulo Arquivos de Neuro-Psiquiatria 01-11-2023 Thieme Revinter Publicações Ltda Academia Brasileira de Neurologia (ABNEURO)
Subjects:	Atrophy Brain stem Cerebellar ataxia Cerebellum Globus pallidus Images in Neurology Machado-Joseph disease Neurodegeneration Spinocerebellar ataxia
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	A 69-year-old male patient with Machado-Joseph disease (MJD) presented with mild cerebellar ataxia, global areflexia, and nystagmus. MRI showed cerebellar and brainstem atrophy, as well as abnormal hyperintensity along the medial aspect of the globus pallidus intemus. This finding suggests degeneration of the lenticular fasciculus and may be associated with degeneration of other neural fibers. While not specific to MJD, similar findings have been observed in other types of spinocerebellar ataxias and in healthy elderly individuals.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0004-282X 1678-4227
DOI:	10.1055/s-0043-1772605