Cutaneous dendritic cells

Cutaneous dendritic cells

Cutaneous dendritic cells (DC) include epidermal Langerhans cells (LC), interstitial/dermal dendritic cells (DDC), as well as plasmacytoid DC (pDC) that occur under pathological conditions. These immune cells have a spectrum of different functions with implications that extend far beyond the skin. T...

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Bibliographic Details
Published in:Seminars in immunology Vol. 17; no. 4; pp. 273 - 283
Main Authors: Valladeau, Jenny, Saeland, Sem
Format: Journal Article
Language:English
Published: England Elsevier Ltd 01-08-2005
Subjects:
Animals
Antigen capture
Antigens - immunology
Cell Differentiation - immunology
Cell Movement - immunology
Dendritic cell migration
Dermal dendritic cells
Epidermis - cytology
Epidermis - immunology
Humans
Langerhans cells
Langerhans Cells - cytology
Langerhans Cells - immunology
Macrophages - immunology
Mice
Skin
Langerhans cells
Dendritic cell migration
Dermal dendritic cells
Skin
Antigen capture
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Description
Summary:Cutaneous dendritic cells (DC) include epidermal Langerhans cells (LC), interstitial/dermal dendritic cells (DDC), as well as plasmacytoid DC (pDC) that occur under pathological conditions. These immune cells have a spectrum of different functions with implications that extend far beyond the skin. They have the potential to internalize particulate agents and macromolecules, and display migratory properties that endow them with the unique capacity to journey between skin and draining lymph nodes where they encounter antigen-specific T lymphocytes. Herein, we will review the features of human and mouse cutaneous DC, emphasizing characteristics representative of their life-cycle stages that occur within the skin.
Bibliography:ObjectType-Article-2
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ISSN:1044-5323
1096-3618
DOI:10.1016/j.smim.2005.05.009