Carotid intima-media thickness in hyperlipidemic type I and type II diabetic patients

• Published in: Diabetes care Vol. 20; no. 3; pp. 276 - 280
• Main Authors: KANTERS, S. D. J. M, ALGRA, A, BANGA, J.-D
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01-03-1997
• Subjects: Adult; Age; Age Factors; Angina pectoris; Arteriosclerosis - complications; Arteriosclerosis - diagnostic imaging; Arteriosclerosis - physiopathology; Atherosclerosis; Biological and medical sciences; Blood pressure; Cardiovascular disease; Cardiovascular system; Carotid arteries; Carotid Artery, Common - diagnostic imaging; Carotid Artery, Common - physiopathology; Cholesterol; Clinical trials; Diabetes; Diabetes Mellitus, Type 1 - complications; Diabetes Mellitus, Type 1 - diagnostic imaging; Diabetes Mellitus, Type 1 - physiopathology; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - diagnostic imaging; Diabetes Mellitus, Type 2 - physiopathology; Diabetic Angiopathies - complications; Diabetic Angiopathies - diagnostic imaging; Diabetic Angiopathies - physiopathology; Female; Glucose; High density lipoprotein; Humans; Hyperlipidemia; Hyperlipidemias - complications; Hyperlipidemias - physiopathology; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Middle Aged; Mortality; Multivariate Analysis; Regression analysis; Risk Factors; Ultrasonic investigative techniques; Ultrasonography; Endocrinopathy; Sonography; Human; Immunopathology; Media; Autoimmune disease; Metabolic diseases; Lipids; Non insulin dependent diabetes; Statistical study; Thickness measurement; Association; Carotid; Echography; Insulin dependent diabetes; Intima; Hyperlipemia; Measurement method; Dyslipemia
• ISSN: 0149-5992; 1935-5548
• DOI: 10.2337/diacare.20.3.276

Carotid intima-media thickness in hyperlipidemic type I and type II diabetic patients.
S D Kanters ,
A Algra and
J D Banga
Department of Internal Medicine, University Hospital, Utrecht, The Netherlands.
Abstract
OBJECTIVE: Ultrasonographic measurements of the combined thickness of the carotid intima and media can be used to examine
early vessel wall changes in atherosclerosis. Premature atherosclerosis is common in diabetes, especially when other risk
factors are present. Intima-media thickness was quantified in hyperlipidemic type I and type II diabetic patients, and relationships
between various risk factors and intima-media thickness were investigated. RESEARCH DESIGN AND METHODS: Thirty-one patients
with type I diabetes and 56 with type II diabetes were examined, with an LDL cholesterol of > 2.6 mmol/l and/or triglycerides
of > 1.7 mmol/l and/or HDL cholesterol of < 0.9 mmol/l for men or < 1.1 mmol/l for women. Intima-media thickness was measured
on-line, over a length of 1 cm in the common carotid artery. Later, the mean and the maximum of six measurements was calculated
(left and right side, both in three directions). RESULTS: Mean intima-media thickness was 0.63 +/- 0.18 (+/-SD) mm for type
I diabetes and 0.80 +/- 0.31 mm for type II diabetes. Adjusted for age, the difference was 0.06 mm, with a 95% CI of -0.08
to 0.20 mm. In multivariate regression analysis, age over 50 years and higher HbA1c were independently associated with an
increase in mean intima-media thickness in type I diabetes. In type II diabetes, none of the variables reached a significance
level of < or = 0.10. Results for maximum intima-media thickness were essentially the same. CONCLUSIONS: In general, intima-media
thickness is larger in type II diabetes than in type I diabetes. The effect of age is absent in type II diabetes, whereas
in type I diabetes, age and blood glucose control have an important effect on intima-media thickness.