Branched-Chain Amino Acids Enhance the Cognitive Recovery of Patients With Severe Traumatic Brain Injury

• Published in: Archives of physical medicine and rehabilitation Vol. 86; no. 9; pp. 1729 - 1735
• Main Authors: Aquilani, Roberto, Iadarola, Paolo, Contardi, Antonella, Boselli, Mirella, Verri, Manuela, Pastoris, Ornella, Boschi, Federica, Arcidiaco, Patrizia, Viglio, Simona
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01-09-2005; Elsevier
• Subjects: Adolescent; Adult; Amino acids, branched-chain; Amino Acids, Branched-Chain - administration & dosage; Biological and medical sciences; Brain injuries; Brain Injuries - diagnosis; Brain Injuries - drug therapy; Cognition Disorders - drug therapy; Cognition Disorders - prevention & control; Disability Evaluation; Diseases of the digestive system; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Infusions, Intravenous; Injuries of the nervous system and the skull. Diseases due to physical agents; Injury Severity Score; Male; Medical sciences; Middle Aged; Miscellaneous; Probability; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Reference Values; Rehabilitation; Risk Assessment; Traumas. Diseases due to physical agents; Treatment Outcome; Amino acids, branched-chain; Brain injuries; Rehabilitation; Brain; Intravenous administration; Tryptamine derivatives; Amino acids; Cognition; Recovery; Encephalon; Blood plasma; Prevention; Branched chain; Reeducation; Neuromediator; Supplementation; Human; Tyrosine; Nervous system diseases; Serotonin; Tryptophan; Concentration; Catecholamine; Care; Diet therapy; Aminoacid; branched-chain; Brain injuries; Rehabilitation; Neurotransmitter; Rehabilitation(human); Head trauma
• ISSN: 0003-9993; 1532-821X
• DOI: 10.1016/j.apmr.2005.03.022

Aquilani R, Iadarola P, Contardi A, Boselli M, Verri M, Pastoris O, Boschi F, Arcidiaco P, Viglio S. Branched-chain amino acids enhance the cognitive recovery of patients with severe traumatic brain injury.
To investigate whether supplementation with branched-chain amino acids (BCAAs) in patients with severe traumatic brain injury (TBI) improves recovery of cognition and influences plasma concentrations of tyrosine and tryptophan, which are precursors of, respectively, catecholamine and serotonin neurotransmitters in the brain.
Forty patients with TBI were randomly assigned to 15 days of intravenous BCAA supplementation (19.6g/d) (n=20) or an isonitrogenous placebo (n=20).
Tertiary care rehabilitation setting in Italy.
Forty men (mean age, 32±15y) with TBI and 20 healthy subjects (controls) matched for age, sex, and sedentary lifestyle.
Supplementation with BCAAs.
Disability Rating Scale (DRS) and plasma concentrations of BCAAs, tyrosine, and tryptophan.
Fifteen days after admission to the rehabilitation department, the DRS score had improved significantly in both the placebo group (
P<.05 vs baseline) and in the BCAA-supplemented group (
P<.01 vs baseline). The difference between the 2 groups was significant (
P<.004). Plasma tyrosine concentration improved in the group given BCAA supplementation, and tryptophan concentration increased in patients receiving placebo.
Supplemental BCAAs enhance the retrieval of DRS without causing negative effects on tyrosine and tryptophan concentration.