Elastomeric biocomposite of silver-containing mesoporous bioactive glass and poly(1,8-octanediol citrate): Physiochemistry and in vitro antibacterial capacity in tissue engineering applications

• Published in: Materials Science & Engineering C Vol. 98; pp. 1022 - 1033
• Main Authors: Pourshahrestani, Sara, Zeimaran, Ehsan, Kadri, Nahrizul Adib, Gargiulo, Nicola, Jindal, Hassan Mahmood, Hasikin, Khairunnisa, Naveen, Sangeetha Vasudevaraj, Sekaran, Shamala Devi, Kamarul, Tunku
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01-05-2019; Elsevier BV
• Subjects: Antibacterial property; Biocompatibility; Biodegradation; Bioglass; Biological activity; Biological properties; Biomedical materials; Citric acid; Composite materials; E coli; Elastomers; Leaching; Materials science; Mechanical properties; Mesoporous bioactive glass; Physiochemistry; Poly(1,8-octanediol citrate); Scaffolds; Silver; Skin; Synergistic effect; Thermodynamic properties; Tissue engineering; Water uptake; Weight; Poly(1,8-octanediol citrate); Silver; Biocompatibility; Antibacterial property; Tissue engineering; Mesoporous bioactive glass
• ISSN: 0928-4931; 1873-0191
• DOI: 10.1016/j.msec.2019.01.022

A novel series of silver-doped mesoporous bioactive glass/poly(1,8-octanediol citrate) (AgMBG/POC) elastomeric biocomposite scaffolds were successfully constructed by a salt-leaching technique for the first time and the effect of inclusion of different AgMBG contents (5, 10, and 20 wt%) on physicochemical and biological properties of pure POC elastomer was evaluated. Results indicated that AgMBG particles were uniformly dispersed in the POC matrix and increasing the AgMBG concentration into POC matrix up to 20 wt% enhanced thermal behaviour, mechanical properties and water uptake ability of the composite scaffolds compared to those from POC. The 20%AgMBG/POC additionally showed higher degradation rate in Tris(hydroxymethyl)-aminomethane–HCl (Tris–HCl) compared with pure POC and lost about 26% of its initial weight after soaking for 28 days. The AgMBG phase incorporation also significantly endowed the resulting composite scaffolds with efficient antibacterial properties against Escherichia coli and Staphylococcus aureus bacteria while preserving their favorable biocompatibility with soft tissue cells (i.e., human dermal fibroblast cells). Taken together, our results suggest that the synergistic effect of both AgMBG and POC make these newly designed AgMBG/POC composite scaffold an attractive candidate for soft tissue engineering applications.
A novel silver-containing mesoporous bioactive glass/poly(1,8-octanediol citrate) (AgMBG/POC) elastomeric biocomposite scaffolds has been synthesized by salt-leaching technique for tissue engineering application. [Display omitted]
•AgMBG/POC elastomeric biocomposite scaffolds were developed by salt-leaching technique.•The incorporation of AgMBG into POC matrix improved water absorption and degradability of biocomposite scaffolds.•The viability of E. coli and S. aureus was significantly reduced by biocomposites.•Elastomeric biocomposites were biocompatible toward human dermal fibroblast cells.