PTEN regulates motility but not directionality during leukocyte chemotaxis

The localization at opposite cell poles of phosphatidylinositol-3 kinases and PTEN (phosphatase and tensin homolog on chromosome 10) governs Dictyostelium chemotaxis. To study this model in mammalian cells, we analyzed the dynamic redistribution of green fluorescent protein (GFP)-tagged PTEN chimera...

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Bibliographic Details
Published in:	Journal of cell science Vol. 117; no. Pt 25; pp. 6207 - 6215
Main Authors:	Lacalle, Rosa Ana, Gómez-Moutón, Concepción, Barber, Domingo F, Jiménez-Baranda, Sonia, Mira, Emilia, Martínez-A, Carlos, Carrera, Ana C, Mañes, Santos
Format:	Journal Article
Language:	English
Published:	England 01-12-2004
Subjects:	Actins - metabolism Blotting, Western Catalysis Cell Movement Chemotactic Factors - pharmacology Chemotaxis Cloning, Molecular Cytoplasm - metabolism Cytosol - metabolism Dictyostelium DNA, Complementary - metabolism Dose-Response Relationship, Drug Green Fluorescent Proteins - metabolism HL-60 Cells Humans Jurkat Cells Leukocytes - cytology Membrane Microdomains - metabolism Microscopy, Fluorescence Microscopy, Video Phosphatidylinositol 3-Kinases - metabolism Phosphoric Monoester Hydrolases - metabolism Phosphoric Monoester Hydrolases - physiology Protein Structure, Tertiary PTEN Phosphohydrolase RNA, Small Interfering - metabolism Subcellular Fractions - metabolism Time Factors Tumor Suppressor Proteins - metabolism Tumor Suppressor Proteins - physiology
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