Clinical Outcomes of Failing to Dose-Reduce Cephalosporin Antibiotics in Older Adults with CKD

Current dosing recommendations for cephalosporin antibiotics are on the basis of pharmacokinetic studies and are frequently ignored in practice. This study was undertaken to investigate the clinical outcomes of failing to dose-reduce cephalosporin antibiotics in CKD. Retrospective cohort study condu...

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Bibliographic Details
Published in:	Clinical journal of the American Society of Nephrology Vol. 14; no. 2; pp. 197 - 205
Main Authors:	Bathini, Lavanya, Jandoc, Racquel, Kuwornu, Paul, McArthur, Eric, Weir, Matthew A, Sood, Manish M, Battistella, Marisa, Muanda, Flory T, Liu, Aiden, Jain, Arsh K, Garg, Amit X
Format:	Journal Article
Language:	English
Published:	United States American Society of Nephrology 07-02-2019
Subjects:	Aged Aged, 80 and over Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - adverse effects Cefprozil Cefuroxime - administration & dosage Cefuroxime - adverse effects Cephalexin - administration & dosage Cephalexin - adverse effects Cephalosporins - administration & dosage Cephalosporins - adverse effects Databases, Factual Emergency Service, Hospital - statistics & numerical data Female Glomerular Filtration Rate Hospitalization - statistics & numerical data Humans Male Mortality Original Renal Insufficiency, Chronic - physiopathology Retrospective Studies Treatment Failure Confidence Intervals Renal Insufficiency, Chronic hospitalization glomerular filtration rate Risk Emergency Service Cefuroxime Anti-Bacterial Agents Outpatients Cephalosporins Cephalexin Treatment Failure cefprozil Aged, 80 and over Aged Retrospective Studies Hospital Odds Ratio renal dialysis
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