Identification of Emerging Macrophage-Tropic HIV-1 R5 Variants in Brain Tissue of AIDS Patients without Severe Neurological Complications

Untreated HIV-positive (HIV-1 ) individuals frequently suffer from HIV-associated neurocognitive disorders (HAND), with about 30% of AIDS patients suffering severe HIV-associated dementias (HADs). Antiretroviral therapy has greatly reduced the incidence of HAND and HAD. However, there is a continuin...

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Bibliographic Details
Published in:	Journal of virology Vol. 91; no. 20
Main Authors:	Gonzalez-Perez, Maria Paz, Peters, Paul J, O'Connell, Olivia, Silva, Nilsa, Harbison, Carole, Cummings Macri, Sheila, Kaliyaperumal, Saravanan, Luzuriaga, Katherine, Clapham, Paul R
Format:	Journal Article
Language:	English
Published:	United States American Society for Microbiology 15-10-2017
Subjects:	Acquired Immunodeficiency Syndrome - complications Acquired Immunodeficiency Syndrome - drug therapy Acquired Immunodeficiency Syndrome - virology Blood-Brain Barrier Brain - virology Genes, env HIV-1 - genetics HIV-1 - isolation & purification HIV-1 - physiology Humans Macrophages - virology Viral Tropism Virion - genetics Virus Replication Virus-Cell Interactions human immunodeficiency virus tropism neurotropism macrophage tropism brain envelope glycoprotein
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