The effects of erythropoietin on neurogenesis after ischemic stroke

Erythropoietin has been researched for its neuroprotective effects in ischemic stroke for over 30 years. Although erythropoietin can cause side effects that need to be controlled, it has been suggested to be effective in enhancing the prognosis of patients who are out of the therapeutic time window...

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Bibliographic Details
Published in:	Journal of integrative neuroscience Vol. 19; no. 3; pp. 561 - 570
Main Authors:	Zhang, Si-Jia, Luo, Yu-Min, Wang, Rong-Liang
Format:	Journal Article
Language:	English
Published:	IMR Press 30-09-2020
Subjects:	erythropoietin\|neurogenesis\|ischemic stroke\|clinical translation\|neurology
Online Access:	Get full text
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Summary:	Erythropoietin has been researched for its neuroprotective effects in ischemic stroke for over 30 years. Although erythropoietin can cause side effects that need to be controlled, it has been suggested to be effective in enhancing the prognosis of patients who are out of the therapeutic time window and have not received recombinant tissue plasminogen activator therapy. Studies on the mechanism of the function of erythropoietin have shown that it has various protective effects in ischemic brain injury after stroke, including promoting neurogenesis. In this review, we discuss the effects of erythropoietin on neurogenesis after ischemic brain injury and provide references for effective treatments for ischemic stroke, which is one of the leading causes of death worldwide.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1757-448X 0219-6352
DOI:	10.31083/j.jin.2020.03.4