NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy

Pregnancy is a common immunization event, but the molecular mechanisms and immunological consequences provoked by pregnancy remain largely unknown. We used mouse models and human transplant registry data to reveal that pregnancy induced exhausted CD8 T cells (Preg-TEX), which associated with prolong...

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Bibliographic Details
Published in:	The Journal of experimental medicine Vol. 219; no. 1
Main Authors:	Lewis, Emma L, Xu, Rong, Beltra, Jean-Christophe, Ngiow, Shin Foong, Cohen, Jordana, Telange, Rahul, Crane, Alexander, Sawinski, Deirdre, Wherry, E John, Porrett, Paige M
Format:	Journal Article
Language:	English
Published:	United States Rockefeller University Press 03-01-2022
Subjects:	Adoptive Transfer Animals Antigens - immunology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Chlorocebus aethiops Female Gene Expression Profiling - methods Homeodomain Proteins - genetics Homeodomain Proteins - immunology Homeodomain Proteins - metabolism Humans Kaplan-Meier Estimate Lymphocyte Activation - genetics Lymphocyte Activation - immunology Lymphocytic Choriomeningitis - immunology Lymphocytic Choriomeningitis - virology Lymphocytic choriomeningitis virus - immunology Lymphocytic choriomeningitis virus - physiology Mice Mice, Inbred C57BL Mice, Transgenic NFATC Transcription Factors - genetics NFATC Transcription Factors - immunology NFATC Transcription Factors - metabolism Pregnancy Programmed Cell Death 1 Receptor - genetics Programmed Cell Death 1 Receptor - immunology Programmed Cell Death 1 Receptor - metabolism Skin Transplantation Spleen - cytology Spleen - immunology Spleen - metabolism Tolerance Vero Cells
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