Trisomy X conferring moderate hemophilia A by extremely skewed X-chromosome inactivation

Hemophilia carriers occasionally present with bleeding tendency due to skewed inactivation of normal F8 carrying X chromosome. Can extreme skewing of X-chromosome inactivation (XCI) with trisomy X cause low factor (F) VIII activity and bleeding in a hemophilia carrier?. A young female with low FVIII...

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Bibliographic Details

Published in:	Research and practice in thrombosis and haemostasis Vol. 7; no. 7; p. 102233
Main Authors:	Shinozawa, Keiko, Niiya, Kenji, Fujimoto, Seiichi, Bingo, Masato, Fukutake, Katsuyuki, Kinai, Ei
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-10-2023
Subjects:	hemophilia A hemophilia carrier methylation skewed X-chromosome inactivation trisomy X X chromosome trisomy X hemophilia A hemophilia carrier methylation X chromosome skewed X-chromosome inactivation
Online Access:	Get full text
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