Cytoprotective effect of Fridericia chica (Bonpl.) L.G. Lohmann extract associated with geranylgeraniol enriched-fraction from Bixa orellana L. on epithelial cells treated with bisphosphonate

• Published in: Natural product research Vol. 37; no. 16; pp. 2776 - 2781
• Main Authors: Machado Júnior, Rogério José, Camilli, Júlia C, Basting, Rosanna Tarkany, Zago, Patrícia Maria Wiziacki, Sousa, Ilza Maria de Oliveira, Buglio, Kaio Eduardo, Ruiz, Ana Lúcia T G, Carvalho, Paulo Roberto Nogueira, Carvalho, João Ernesto de, Saad, Sara T O, Foglio, Mary Ann
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis Ltd 01-08-2023
• Subjects: Bisphosphonates; Bone diseases; Cell viability; Epithelial cells; Epithelium; Ethanol; Fridericia chica; Jaw; Keratinocytes; Osteonecrosis; Synergistic effect; Tumor cells; Wound healing; Zoledronic acid; Arrabidaea chica Verlot; cell viability; Bisphosphonates; Fridericia chica (Bonpl.) L.G.Lohmann
• ISSN: 1478-6419; 1478-6427
• DOI: 10.1080/14786419.2022.2131782

Bisphosphonates are drugs used to treat bone disorders. The chronic use of bisphosphonates is associated with the occurrence of medication-related osteonecrosis of the jaw (MRONJ). Previous data reported the positive effects of Geranylgeraniol on different cell types treated with Bisphosphonates. Foregoing work done by our research group demonstrated the wound healing capacity of
(Bonpl.) L.G.Lohmann standardized ethanol extract. Herein
cytoprotective synergistic effect of the association of
extract associated with an enriched geranylgeraniol fraction on keratinocytes exposed to zoledronic acid is reported. An association of
at 1 and 5 µg/mL with geranylgeraniol at 15 µg/mL, increased cell viability by 73.5% and 71.1%, respectively. This treatment did not increase tumor cells viability; whereas the clonogenic potential assessment showed that, the association with
(5 µg/mL) reversed the effects of zoledronic acid on the cells. This study provides data for a potential treatment for MRONJ.