Definition of a putative pathological region in PARK2 associated with autism spectrum disorder through in silico analysis of its functional structure

OBJECTIVEThe PARK2 gene encodes Parkin, a component of a multiprotein E3 ubiquitin ligase complex that targets substrate proteins for proteasomal degradation. PARK2 mutations are frequently associated with Parkinson’s disease, but structural alterations have also been described in patients with neur...

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Bibliographic Details
Published in:	Psychiatric genetics Vol. 27; no. 2; pp. 54 - 61
Main Authors:	Conceição, Inês C, Rama, Maria M, Oliveira, Bárbara, Café, Cátia, Almeida, Joana, Mouga, Susana, Duque, Frederico, Oliveira, Guiomar, Vicente, Astrid M
Format:	Journal Article
Language:	English
Published:	England Copyright Wolters Kluwer Health, Inc. All rights reserved 01-04-2017
Subjects:	Autism Spectrum Disorder - genetics Autism Spectrum Disorder - metabolism Computer Simulation DNA Copy Number Variations Female Humans Male Mutation Neurodevelopmental Disorders - genetics Neurodevelopmental Disorders - metabolism Parkinson Disease - genetics Parkinson Disease - metabolism Portugal Structure-Activity Relationship Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism
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