Prenatal maternal glucocorticoid exposure modifies sperm miRNA profiles across multiple generations in the guinea‐pig

Maternal stress and glucocorticoid exposure during pregnancy have multigenerational effects on neuroendocrine function and behaviours in offspring. Importantly, effects are transmitted through the paternal lineage. Altered phenotypes are associated with profound differences in transcription and DNA...

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Bibliographic Details
Published in:	The Journal of physiology Vol. 602; no. 9; pp. 2127 - 2139
Main Authors:	Hamada, Hirotaka, Casciaro, Christopher, Moisiadis, Vasilis G., Constantinof, Andrea, Kostaki, Alisa, Matthews, Stephen G.
Format:	Journal Article
Language:	English
Published:	England Wiley Subscription Services, Inc 01-05-2024
Subjects:	DNA methylation Epididymis Epigenetics Gene expression Germ cells Glucocorticoids glucocorticoids (betamethasone) MicroRNAs miRNA Neuroendocrine system Offspring Phenotypes Prefrontal cortex Pregnancy Prenatal experience Sperm spermatozoa Testes spermatozoa miRNA glucocorticoids (betamethasone)
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