Metastatic meningioma: Case report of a WHO grade I meningioma with liver metastases and review of the literature

• Published in: Radiology case reports Vol. 15; no. 2; pp. 110 - 116
• Main Authors: Beutler, Bryce D., Nguyen, Emilie T., Parker, Rex A., Tran, Clement, Acharya, Jay, Torres, Fernando A., Gullapalli, Nageshwara
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01-02-2020; Elsevier
• Subjects: Central nervous system neoplasms; Liver metastases; Meningioma; Meningioma staging; Metastatic meningioma; Neuroradiology; WHO grade I meningioma; Central nervous system neoplasms; Liver metastases; Meningioma staging; WHO grade I meningioma; Meningioma; Metastatic meningioma
• ISSN: 1930-0433; 1930-0433
• DOI: 10.1016/j.radcr.2019.10.027

Meningioma represents the most frequently diagnosed primary brain tumor, accounting for over one-third of central nervous system neoplasms. The majority of tumors are categorized as benign. However, albeit rarely, meningiomas may metastasize to distant sites. We describe a 78-year-old man with a history of recurrent World Health Organization grade I meningioma managed who presented for evaluation of weakness and urinary retention. A computed tomography scan obtained in the emergency department revealed multiple scattered low-density liver lesions. Subsequent magnetic resonance imaging showed a 5.5-centimeter heterogeneous enhancing mass with 2 smaller enhancing lesions suspicious for a primary or secondary malignant neoplasm. Microscopic examination of a tissue sample obtained via liver biopsy demonstrated a metastatic spindle cell neoplasm with histologic features compatible with a diagnosis of World Health Organization grade I transitional meningioma. The patient was referred to hematology/oncology for systemic therapy.