Structural domains of thrombin involved in the induction of mitogenesis in cultured human vascular smooth muscle cells

Human alpha-thrombin is a known human vascular smooth muscle cell (HVSMC) mitogen. We have previously reported that gamma-thrombin, in which the anion binding exosite is disrupted, but not catalytically inactivated PPACK-thrombin is mitogenic on HVSMC. Here, the structural requirements for thrombin&...

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Bibliographic Details
Published in:	Blood coagulation & fibrinolysis Vol. 6; no. 7; p. 634
Main Authors:	Kanthou, C, Dennehy, U, Kakkar, V V, Benzakour, O
Format:	Journal Article
Language:	English
Published:	England 01-10-1995
Subjects:	Amino Acid Chloromethyl Ketones - pharmacology Amino Acid Sequence Antithrombin III - pharmacology Antithrombins - pharmacology Binding Sites Cells, Cultured DNA - biosynthesis Hirudins - pharmacology Humans Kinetics Mitogens - pharmacology Molecular Sequence Data Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - drug effects Platelet-Derived Growth Factor - genetics Proto-Oncogene Proteins c-fos - biosynthesis Structure-Activity Relationship Thrombin - antagonists & inhibitors Thrombin - chemistry Thrombin - pharmacology
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