Prothrombin fragment 1 + 2 and thrombin-antithrombin III complex as markers of activation of blood coagulation in inflammatory bowel diseases

• Published in: European journal of gastroenterology & hepatology Vol. 7; no. 12; p. 1183
• Main Authors: Chamouard, P, Grunebaum, L, Wiesel, M L, Frey, P L, Wittersheim, C, Sapin, R, Baumann, R, Cazenave, J P
• Format: Journal Article
• Language: English
• Published: England 01-12-1995
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Antibodies, Anticardiolipin - metabolism; Antithrombin III - metabolism; Biomarkers - blood; Blood Coagulation; C-Reactive Protein - metabolism; Colitis, Ulcerative - blood; Crohn Disease - blood; Female; Humans; Male; Middle Aged; Peptide Fragments - metabolism; Peptide Hydrolases - metabolism; Prothrombin - metabolism; Thrombomodulin - metabolism; Thrombosis - blood; Tumor Necrosis Factor-alpha - metabolism
• ISSN: 0954-691X
• DOI: 10.1097/00042737-199512000-00010

The aims of the present work were to assess the presence of thrombin generation in Crohn's disease and in ulcerative colitis by using the prothrombin fragment 1 + 2 and the thrombin-antithrombin III complex assays and to study the possible relationships between these markers and disease activity.
Prothrombin fragment 1 + 2 and thrombin-antithrombin III complex were significantly raised in patients with Crohn's disease (n = 69) and with ulcerative colitis (n = 25) as compared with healthy controls (n = 50). In Crohn's disease these two markers of thrombin generation were correlated with the Van Hees index (P < 0.05 and P < 0.001, respectively); values were significantly different from controls even in the patient group displaying the lowest disease activity (P < 0.001). No correlation was found with tumour necrosis factor alpha and C-reactive protein; nevertheless patients with C-reactive protein less than or equal to 10 mg/l had significant lower values of prothrombin fragment 1 + 2 (P < 0.03). In ulcerative colitis prothrombin fragment 1 + 2 and thrombin-antithrombin III complex were significantly increased by comparison with controls, were higher in patients with pancolitis and correlated with C-reactive protein (P < 0.002 and P < 0.009, respectively).
These data show that prothrombin fragment 1 + 2 and thrombin-antithrombin III complex are increased in inflammatory bowel diseases and suggest that thrombin generation might be an early event in their pathogenesis.