Physiological and radio-induced modulations of low-weight globulins in distinct vascular compartments

• Published in: Journal of radioanalytical and nuclear chemistry Vol. 318; no. 2; pp. 1317 - 1324
• Main Authors: Lima, Celso Vieira, de Campos, Tarcísio Passos Ribeiro, Valencia, Carlos Julio Montano, Almeida, Iassudara Garcia
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01-11-2018; Springer; Springer Nature B.V
• Subjects: Albumin; Blood proteins; Chemistry; Chemistry and Materials Science; Diagnostic Radiology; Electrophoresis; Gamma rays; Gene expression; Globulins; Hadrons; Heavy Ions; Inorganic Chemistry; Ionizing radiation; Kidneys; Molecular weight; Nuclear Chemistry; Nuclear Physics; Physical Chemistry; Physiology; Radio; Spleen; Rats; Electrophoresis; Serum protein; Globulin; Radiation
• ISSN: 0236-5731; 1588-2780
• DOI: 10.1007/s10967-018-6188-3

The main goal was to investigate the profiles of molecular weight globulins lower than albumin in the electrophoresis system in function of the exposition time to gamma radiation. At 72 h post-irradiation, the globulin electrophoretic profiles bellow albumin showed significant radio-induced changes. In addition, the vascular system, specifically the inferior vena cava, kidney, spleen, jugular, hepatic, and pulmonary veins presented a physiological compartmental distribution of globulins. The findings pointed out the radio-induced alterations of the serum globulin concentrations as a late event, possibly related to a radio modulation of the genes’ expression.