Synthesis, Structure, and Biological Activity of Palladium(II) Complexes with Some 1- and 2-Substituted Tetrazole Ligands

• Published in: Russian journal of general chemistry Vol. 91; no. 4; pp. 666 - 671
• Main Authors: Batyrenko, A. A., Mikolaichuk, O. V., Ovsepyan, G. K., Protas, A. V., Kornyakov, I. V., Lider, E. V., Eremina, Yu. A., Khlebnikova, T. S., Lakhvich, F. A., Trifonov, R. E.
• Format: Journal Article
• Language: English
• Published: Moscow Pleiades Publishing 01-04-2021; Springer; Springer Nature B.V
• Subjects: Amino acids; Biological activity; Chemistry; Chemistry and Materials Science; Chemistry/Food Science; Crystals; Diffraction; Ligands; Mass spectrometry; NMR spectroscopy; Nuclear magnetic resonance spectroscopy; Palladium; Single crystals; Spectrophotometry; Tetrazoles; X-rays; 1; tetrazol-1-ylcarboxylic acids; interaction with DNA; tetrazoles; Pd(II) complexes; DNA melting point; cytotoxic activity
• ISSN: 1070-3632; 1608-3350
• DOI: 10.1134/S1070363221040149

A series of palladium(II) complexes with 1
H
- and 2
H
-tetrazole ligands (2-isopropyl-5-R-2
H
-tetrazoles and 1
H
-tetrazol-1-ylcarboxylic acids) was synthesized. Structure of the obtained compounds was confirmed by
1
H and
13
C NMR spectroscopy, high-resolution mass spectrometry, and single crystal X-ray diffraction analysis. According to the spectrophotometry data, the complexes are weakly bound to DNA. The cytotoxic activity of the obtained palladium complexes was studied
in vitro
.