Macrophages, the main marker in biocompatibility evaluation of new hydrogels after subcutaneous implantation in rats

Macrophages, the main marker in biocompatibility evaluation of new hydrogels after subcutaneous implantation in rats

Biocompatibility of materials is one of the most important conditions for their successful application in tissue regeneration and repair. Cell-surface interactions stimulate adhesion and activation of macrophages whose acquaintance can assist in designing novel biomaterials that promote favorable ma...

Full description

Saved in:
Bibliographic Details
Published in:Journal of biomaterials applications Vol. 36; no. 6; pp. 1111 - 1125
Main Authors: Lužajić Božinovski, Tijana, Todorović, Vera, Milošević, Ivan, Prokić, Bogomir Bolka, Gajdov, Vladimir, Nešović, Katarina, Mišković-Stanković, Vesna, Marković, Danica
Format: Journal Article
Language:English
Published: London, England SAGE Publications 01-01-2022
Subjects:
skin
macrophages
silver/poly(vinyl alcohol)graphene
Histology
in vivo
rats
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Abstract Biocompatibility of materials is one of the most important conditions for their successful application in tissue regeneration and repair. Cell-surface interactions stimulate adhesion and activation of macrophages whose acquaintance can assist in designing novel biomaterials that promote favorable macrophage–biomaterial surface interactions for clinical application. This study is designed to determine the distribution and number of macrophages as a means of biocompatibility evaluation of two newly synthesized materials [silver/poly(vinyl alcohol) (Ag/PVA) and silver/poly(vinyl alcohol)/graphene (Ag/PVA/Gr) nanocomposite hydrogels] in vivo, with approval of the Ethics Committee of the Faculty of Veterinary Medicine, University of Belgrade. Macrophages and giant cells were analyzed in tissue sections stained by routine H&E and immunohistochemical methods (CD68+). Statistical relevance was determined in the statistical software package SPSS 20 (IBM corp). The results of the study in terms of the number of giant cells localized around the implant showed that their number was highest on the seventh postoperative day (p.o.d.) in the group implanted with Ag/PVA hydrogels, and on the 30th p.o.d. in the group implanted with Ag/PVA/Gr. Interestingly, the number of macrophages measured in the capsular and pericapsular space was highest in the group implanted with the commercial Suprasorb© material. The increased macrophage number, registered around the Ag/PVA/Gr implant on 60th p.o.d. indicates that the addition of graphene can, in a specific way, modulate different biological responses of tissues in the process of wound healing, regeneration, and integration.
AbstractList Biocompatibility of materials is one of the most important conditions for their successful application in tissue regeneration and repair. Cell-surface interactions stimulate adhesion and activation of macrophages whose acquaintance can assist in designing novel biomaterials that promote favorable macrophage-biomaterial surface interactions for clinical application. This study is designed to determine the distribution and number of macrophages as a means of biocompatibility evaluation of two newly synthesized materials [silver/poly(vinyl alcohol) (Ag/PVA) and silver/poly(vinyl alcohol)/graphene (Ag/PVA/Gr) nanocomposite hydrogels] , with approval of the Ethics Committee of the Faculty of Veterinary Medicine, University of Belgrade. Macrophages and giant cells were analyzed in tissue sections stained by routine H&E and immunohistochemical methods (CD68 ). Statistical relevance was determined in the statistical software package SPSS 20 (IBM corp). The results of the study in terms of the number of giant cells localized around the implant showed that their number was highest on the seventh postoperative day (p.o.d.) in the group implanted with Ag/PVA hydrogels, and on the 30th p.o.d. in the group implanted with Ag/PVA/Gr. Interestingly, the number of macrophages measured in the capsular and pericapsular space was highest in the group implanted with the commercial Suprasorb material. The increased macrophage number, registered around the Ag/PVA/Gr implant on 60th p.o.d. indicates that the addition of graphene can, in a specific way, modulate different biological responses of tissues in the process of wound healing, regeneration, and integration.
Biocompatibility of materials is one of the most important conditions for their successful application in tissue regeneration and repair. Cell-surface interactions stimulate adhesion and activation of macrophages whose acquaintance can assist in designing novel biomaterials that promote favorable macrophage–biomaterial surface interactions for clinical application. This study is designed to determine the distribution and number of macrophages as a means of biocompatibility evaluation of two newly synthesized materials [silver/poly(vinyl alcohol) (Ag/PVA) and silver/poly(vinyl alcohol)/graphene (Ag/PVA/Gr) nanocomposite hydrogels] in vivo, with approval of the Ethics Committee of the Faculty of Veterinary Medicine, University of Belgrade. Macrophages and giant cells were analyzed in tissue sections stained by routine H&E and immunohistochemical methods (CD68 + ). Statistical relevance was determined in the statistical software package SPSS 20 (IBM corp). The results of the study in terms of the number of giant cells localized around the implant showed that their number was highest on the seventh postoperative day (p.o.d.) in the group implanted with Ag/PVA hydrogels, and on the 30th p.o.d. in the group implanted with Ag/PVA/Gr. Interestingly, the number of macrophages measured in the capsular and pericapsular space was highest in the group implanted with the commercial Suprasorb © material. The increased macrophage number, registered around the Ag/PVA/Gr implant on 60th p.o.d. indicates that the addition of graphene can, in a specific way, modulate different biological responses of tissues in the process of wound healing, regeneration, and integration.
Biocompatibility of materials is one of the most important conditions for their successful application in tissue regeneration and repair. Cell-surface interactions stimulate adhesion and activation of macrophages whose acquaintance can assist in designing novel biomaterials that promote favorable macrophage–biomaterial surface interactions for clinical application. This study is designed to determine the distribution and number of macrophages as a means of biocompatibility evaluation of two newly synthesized materials [silver/poly(vinyl alcohol) (Ag/PVA) and silver/poly(vinyl alcohol)/graphene (Ag/PVA/Gr) nanocomposite hydrogels] in vivo, with approval of the Ethics Committee of the Faculty of Veterinary Medicine, University of Belgrade. Macrophages and giant cells were analyzed in tissue sections stained by routine H&E and immunohistochemical methods (CD68+). Statistical relevance was determined in the statistical software package SPSS 20 (IBM corp). The results of the study in terms of the number of giant cells localized around the implant showed that their number was highest on the seventh postoperative day (p.o.d.) in the group implanted with Ag/PVA hydrogels, and on the 30th p.o.d. in the group implanted with Ag/PVA/Gr. Interestingly, the number of macrophages measured in the capsular and pericapsular space was highest in the group implanted with the commercial Suprasorb© material. The increased macrophage number, registered around the Ag/PVA/Gr implant on 60th p.o.d. indicates that the addition of graphene can, in a specific way, modulate different biological responses of tissues in the process of wound healing, regeneration, and integration.
Author Marković, Danica
Prokić, Bogomir Bolka
Nešović, Katarina
Lužajić Božinovski, Tijana
Gajdov, Vladimir
Mišković-Stanković, Vesna
Todorović, Vera
Milošević, Ivan
Author_xml – sequence: 1
  givenname: Tijana
  surname: Lužajić Božinovski
  fullname: Lužajić Božinovski, Tijana
  organization: Department of Physical Chemistry and Electrochemistry, Faculty of Technology and Metallurgy
– sequence: 2
  givenname: Vera
  surname: Todorović
  fullname: Todorović, Vera
  organization: Department of Physical Chemistry and Electrochemistry, Faculty of Technology and Metallurgy
– sequence: 3
  givenname: Ivan
  surname: Milošević
  fullname: Milošević, Ivan
  organization: Department of Physical Chemistry and Electrochemistry, Faculty of Technology and Metallurgy
– sequence: 4
  givenname: Bogomir Bolka
  surname: Prokić
  fullname: Prokić, Bogomir Bolka
  organization: Department of Physical Chemistry and Electrochemistry, Faculty of Technology and Metallurgy
– sequence: 5
  givenname: Vladimir
  surname: Gajdov
  fullname: Gajdov, Vladimir
  organization: Department of Physical Chemistry and Electrochemistry, Faculty of Technology and Metallurgy
– sequence: 6
  givenname: Katarina
  surname: Nešović
  fullname: Nešović, Katarina
  organization: Department of Physical Chemistry and Electrochemistry, Faculty of Technology and Metallurgy
– sequence: 7
  givenname: Vesna
  surname: Mišković-Stanković
  fullname: Mišković-Stanković, Vesna
  organization: Department of Physical Chemistry and Electrochemistry, Faculty of Technology and Metallurgy
– sequence: 8
  givenname: Danica
  orcidid: 0000-0002-3403-0473
  surname: Marković
  fullname: Marković, Danica
  organization: Department of Physical Chemistry and Electrochemistry, Faculty of Technology and Metallurgy
BackLink https://www.ncbi.nlm.nih.gov/pubmed/34607494$$D View this record in MEDLINE/PubMed
BookMark eNp9kDtPwzAUhS1URB_wA1iQRwZS_EycEVW8JBALzJHtOG1KEgfbAfXf4yqFBYnF19f3nCPfbw4mne0MAOcYLTHOsmskBKdEEIIxYinG-RGYYU5RIhAhEzDbz5O9YArm3m8RQjxn6QmYUpaijOVsBsKz1M72G7k2_gqGjYGtrLt4uHfjYLyp2mrb9jLUqm7qsIPmUzZDbG0HbQU78wU3u9LZtWk8lFWILj8oPQTZGTt4WLd9I7swGmKek8GfguNKNt6cHeoCvN3dvq4ekqeX-8fVzVOiqaAhIVznKVUCS84pLqWKz4SnShBWas2EMHH9TGvOCKMcozJLCSUKpyVPGUMZXYDLMbd39mMwPhRt7bVpmvFvBeFZTjMRzVGKR2mk4b0zVdG7OlLYFRgVe9jFH9jRc3GIH1Rryl_HD90oWI4CH_EWWzu4Lq77T-I3ieGJbg
CitedBy_id crossref_primary_10_3389_fbioe_2024_1407797
crossref_primary_10_3390_jfb14040227
Cites_doi 10.1002/jbm.820280110
10.1093/rb/rbw001
10.2298/AVB0903243M
10.1002/adfm.201304202
10.1067/mpr.2000.107227
10.2478/acve-2021-0025
10.1111/imr.12223
10.1016/j.compositesb.2017.12.017
10.5562/cca3133
10.1007/978-88-470-1104-5_5
10.1016/j.addr.2016.04.009
10.1002/1097-4636(20011205)57:3<336::AID-JBM1176>3.0.CO;2-E
10.1016/0142-9612(84)90060-7
10.1089/wound.2012.0401
10.1016/S1359-0286(01)00012-2
10.1016/j.jare.2017.01.005
10.1016/j.carbpol.2012.12.043
10.1007/s40204-018-0083-4
10.1002/wnan.1213
10.1021/acs.biomac.8b00444
10.1189/jlb.5VMR0415-166R
10.1006/bbrc.1998.9702
10.1146/annurev-bioeng-071813-104814
10.1023/A:1008976531592
10.1093/rb/rbw006
10.1124/jpet.115.225540
10.1016/j.msec.2017.05.032
10.1021/acsabm.8b00562
10.1016/j.msec.2013.10.006
10.1016/j.jiec.2015.11.016
10.1002/adma.201500411
10.1016/S0142-9612(02)00160-6
10.3390/polym7020186
10.1002/jbm.a.30165
10.1002/jbm.10043
10.2478/acve-2018-0027
10.1016/j.smim.2007.11.004
10.1016/j.jiec.2019.04.022
10.1177/0885328218759564
10.1016/j.etap.2005.07.009
10.1088/1748-6041/1/1/R01
10.1189/jlb.1008588
10.1016/j.biomaterials.2010.08.049
10.1111/cid.12274
10.2298/VETGL210322005P
10.1016/j.biomaterials.2004.06.034
10.1016/j.biomaterials.2009.07.027
10.1016/j.msec.2012.05.016
10.1023/A:1024951330265
10.1016/j.eurpolymj.2019.109257
10.3390/ma8095269
10.1002/(SICI)1097-4636(199905)45:2<148::AID-JBM10>3.0.CO;2-U
10.2298/AVB0804381S
10.1007/978-88-470-1104-5_1
10.1016/j.compositesb.2016.08.024
10.1016/j.carbon.2016.04.046
10.1016/j.carbpol.2016.08.026
10.1002/jbm.a.30313
10.2217/nnm.10.12
10.1002/jbm.820180407
10.12703/P6-13
10.1002/jbm.820280111
10.1016/j.bej.2020.107821
10.1038/s41427-018-0100-z
10.1007/s12325-017-0478-y
10.1089/ten.2006.12.1955
10.1080/08927014.2014.926475
ContentType Journal Article
Copyright The Author(s) 2021
Copyright_xml – notice: The Author(s) 2021
DBID NPM
AAYXX
CITATION
7X8
DOI 10.1177/08853282211046119
DatabaseName PubMed
CrossRef
MEDLINE - Academic
DatabaseTitle PubMed
CrossRef
MEDLINE - Academic
DatabaseTitleList PubMed
CrossRef
DeliveryMethod fulltext_linktorsrc
Discipline Engineering
EISSN 1530-8022
EndPage 1125
ExternalDocumentID 10_1177_08853282211046119
34607494
10.1177_08853282211046119
Genre Research Support, Non-U.S. Gov't
Journal Article
GrantInformation_xml – fundername: Ministarstvo ProsveteNauke i Tehnološkog Razvoja
  grantid: 451-03-9/2021-14/200143; 451-03-9/2021-14/200135; 451-03-9/2021-14/200287
  funderid: https://doi.org/10.13039/501100004564
– fundername: European Union’s Horizon 2020 research and innovation programme
  grantid: 952033
GroupedDBID ---
-MK
-TM
.2G
.2N
.GJ
01A
0R~
1~K
29J
31S
31X
31Y
31Z
4.4
53G
5GY
5VS
AABOD
AACKU
AACTG
AADUE
AAGGD
AAJOX
AAJPV
AAMGE
AANSI
AAPEO
AAQDB
AARIX
AATAA
AATBZ
AAYTG
ABAWP
ABCCA
ABDWY
ABEIX
ABFWQ
ABHKI
ABHQH
ABJIS
ABJNI
ABKRH
ABLUO
ABPNF
ABQKF
ABQXT
ABRHV
ABVVC
ABYTW
ACDXX
ACGBL
ACGFS
ACIWK
ACLZU
ACOFE
ACOXC
ACPRK
ACROE
ACSIQ
ACTQU
ACUAV
ACUIR
ACXKE
ADEIA
ADRRZ
ADTBJ
ADUKL
AEDFJ
AENEX
AEPTA
AEQLS
AESZF
AEUHG
AEUIJ
AEWDL
AEWHI
AEXNY
AFEET
AFKBI
AFKRG
AFMOU
AFQAA
AFUIA
AGKLV
AGNHF
AGWFA
AHHFK
AIOMO
AIZZC
AJEFB
AJUZI
ALFTD
ALJHS
ALMA_UNASSIGNED_HOLDINGS
ANDLU
ARTOV
ASPBG
AUTPY
AUVAJ
AVWKF
AYAKG
AZFZN
B8O
B8Z
B93
B94
BBRGL
BDDNI
BPACV
BYIEH
CAG
CBRKF
CFDXU
COF
CORYS
CS3
DD0
DE-
DH.
DO-
DOPDO
DU5
DV7
D~Y
EBS
EJD
EMOBN
F5P
FEDTE
FHBDP
GROUPED_SAGE_PREMIER_JOURNAL_COLLECTION
HF~
HVGLF
HZ~
J8X
JCYGO
K.F
M4V
N9A
O9-
OVD
P.B
P2P
PQQKQ
Q1R
Q7X
Q82
Q83
ROL
S01
SBI
SCNPE
SFB
SFC
SFK
SFS
SFT
SFX
SGA
SGP
SGV
SGX
SGZ
SPJ
SPP
SPV
SQCSI
STM
TEORI
ZPPRI
ZRKOI
ACJER
AGWNL
H13
NPM
AAYXX
ADVBO
CITATION
7X8
ID FETCH-LOGICAL-c383t-25c963b81a5531dabc38256b824dcc488e8537cc54243510d76232b16d5644073
IEDL.DBID ARPSY
ISSN 0885-3282
IngestDate Fri Oct 25 07:47:11 EDT 2024
Fri Nov 22 01:45:26 EST 2024
Wed Oct 16 00:46:48 EDT 2024
Tue Jul 16 20:51:58 EDT 2024
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 6
Keywords skin
macrophages
silver/poly(vinyl alcohol)graphene
Histology
in vivo
rats
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c383t-25c963b81a5531dabc38256b824dcc488e8537cc54243510d76232b16d5644073
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ORCID 0000-0002-3403-0473
OpenAccessLink https://zenodo.org/records/6079084/files/JBA-21-0233.R1_Proof_hi.pdf
PMID 34607494
PQID 2579378435
PQPubID 23479
PageCount 15
ParticipantIDs proquest_miscellaneous_2579378435
crossref_primary_10_1177_08853282211046119
pubmed_primary_34607494
sage_journals_10_1177_08853282211046119
PublicationCentury 2000
PublicationDate 20220100
2022-01-00
20220101
PublicationDateYYYYMMDD 2022-01-01
PublicationDate_xml – month: 1
  year: 2022
  text: 20220100
PublicationDecade 2020
PublicationPlace London, England
PublicationPlace_xml – name: London, England
– name: England
PublicationTitle Journal of biomaterials applications
PublicationTitleAlternate J Biomater Appl
PublicationYear 2022
Publisher SAGE Publications
Publisher_xml – name: SAGE Publications
References Sood, Granick, Tomaselli 2014; 3
Martinez, Gordon 2014; 6
Loo, Young, Lee 2014; 30
Nešović, Abudabbus, Rhee 2017; 90
Gordon, Plüddemann, Martinez Estrada 2014; 262
Shanbhag, Jacobs, Black 1994; 28
Gonzalez, Ludueña, Ponce 2014; 34
Oliviera, Rouzé, Quilty 2014; 4
Sjögren, Sletten, Dahl 2000; 84
Hench, Thompson 2010; 7
Ohashi, Hattori, Hattori 2015; 354
Geckil, Xu, Zhang 2010; 5
Anderson 2016; 3
Fan, Liu, Wang 2014; 24
Ratner 2016; 3
Nešović, Janković, Radetić 2019; 121
Stojanovic, Janackovic, Markovic 2008; 58
Ross, Auger, Burke 2002; 2
Mir, Ali, Barakullah 2018; 7
Kzhyshkowska, Gudima, Riabov 2015; 98
Ikeda, Ikeda, Sasaki 1998; 253
Surudžić, Janković, Mitrić 2016; 34
Salthouse 1984; 18
Anderson, Defife, McNally 1999; 10
Garrigues, Cho, Rubash 2005; 26
Shen, Horbett 2001; 57
Williams 2006; 21
Sheikh, Brooks, Barzilay 2015; 8
Nešović, Janković, Perić-Grujić 2019; 77
Thompson, Murray, Wallace 2015; 27
Han, Ceilley 2017; 34
Anderson, Miller 1984; 5
Ji, Sun, Qu 2016; 105
Bryant, Peyton 2018; 19
Kamoun, Kenawy, Chen 2017; 8
Sharma, Lizu, Stewart 2015; 7
Xu, Hwang, Bartlett 2021; 165
Prokić, Lužajić Božinovski, Gajdov 2021
Abdelgawad, Hudson, Rojas 2014; 100
Brodbeck, MacEwan, Colton 2005; 74A
Bygd, Ma, Bratlie 2017; 79
Abudabbus, Jevremović, Nešović 2018; 140
Brodbeck, Colton, Anderson 2003; 14
Chen, Cheng, Zhao 2019; 11
LužajićBožinovski, Marković, Todorović 2018; 68
Usman, Hussain, Riaz 2016; 153
Upman, Muench 2004; 23
Hotaling, Tang, Irvine 2015; 17
Hunt, Shoichet 2001; 5
Anderson, Rodriguez, Chang 2008; 20
Luttikhuizen, Harmsen, Luyn 2006; 12
Li, Bratlie 2019; 2
Pencheva, Bryaskova, Kantardjiev 2012; 32
Han, Sun, He 2019; 11
Wu, Liu, Yang 2007; 38
Trindade, Albrektsson, Tengvall 2016; 18
Williams 2009; 30
Kao, Zhao, Hiltner 1994; 28
Hegab, Elmekawy, Zou 2016; 105
Ward, Slobodzian, Tiekotter 2002; 23
Wujcik, Monty 2013; 5
Abudabbus, Jevremović, Janković 2016; 104
Stojkovska, Djurdjevic, Jancic 2018; 32
Dadsetan, Jones, Hiltner 2004; 71A
Collier, Anderson 2002; 60
DeFife, Colton, Nakayama 1999; 45
Xia, Triffitt 2006; 1
Marković, Kojić, Marinković 2009; 59
Li, Fu, Yu 2013; 8
Lužajić Božinovski, Milošević, Todorović 2021; 71
Ye, Harmsen, van Luyn 2010; 31
MacLauchlan, Skokos, Meznarich 2009; 85
bibr19-08853282211046119
bibr3-08853282211046119
bibr61-08853282211046119
bibr54-08853282211046119
bibr26-08853282211046119
bibr74-08853282211046119
bibr67-08853282211046119
bibr13-08853282211046119
Wu JQ (bibr5-08853282211046119) 2007; 38
bibr8-08853282211046119
bibr20-08853282211046119
bibr66-08853282211046119
bibr40-08853282211046119
bibr53-08853282211046119
bibr33-08853282211046119
bibr73-08853282211046119
bibr9-08853282211046119
bibr39-08853282211046119
bibr59-08853282211046119
Ross J (bibr56-08853282211046119) 2002; 2
Li C (bibr27-08853282211046119) 2013; 8
Chen H (bibr29-08853282211046119) 2019; 11
bibr48-08853282211046119
Williams DF (bibr2-08853282211046119) 2004
bibr12-08853282211046119
bibr58-08853282211046119
bibr22-08853282211046119
bibr70-08853282211046119
bibr60-08853282211046119
bibr52-08853282211046119
bibr42-08853282211046119
bibr32-08853282211046119
bibr62-08853282211046119
bibr68-08853282211046119
bibr18-08853282211046119
bibr72-08853282211046119
bibr17-08853282211046119
bibr37-08853282211046119
bibr47-08853282211046119
bibr57-08853282211046119
bibr7-08853282211046119
Han S (bibr38-08853282211046119) 2019; 11
bibr71-08853282211046119
Oliviera RN (bibr28-08853282211046119) 2014; 4
bibr41-08853282211046119
bibr31-08853282211046119
bibr11-08853282211046119
bibr21-08853282211046119
bibr51-08853282211046119
bibr64-08853282211046119
bibr6-08853282211046119
bibr16-08853282211046119
bibr10-08853282211046119
bibr43-08853282211046119
bibr30-08853282211046119
bibr63-08853282211046119
bibr23-08853282211046119
Hench LL (bibr46-08853282211046119) 2010; 7
bibr50-08853282211046119
bibr49-08853282211046119
bibr36-08853282211046119
bibr69-08853282211046119
bibr35-08853282211046119
bibr65-08853282211046119
bibr15-08853282211046119
Upman PJ (bibr1-08853282211046119) 2004; 23
bibr25-08853282211046119
bibr75-08853282211046119
bibr45-08853282211046119
bibr55-08853282211046119
bibr14-08853282211046119
bibr34-08853282211046119
bibr44-08853282211046119
bibr24-08853282211046119
bibr4-08853282211046119
References_xml – volume: 7
  start-page: 186
  year: 2015
  end-page: 219
  article-title: Multifunctional nanofibers towards active biomedical therapeutics
  publication-title: Polymers
  contributor:
    fullname: Stewart
– volume: 71
  issue: 3
  year: 2021
  article-title: Evaluation of soft tissue regenerative process after subcutaneous implantation of silver/poly(vinyl alcohol) and novel silver/poly(vinyl alcohol)/graphene hydrogels in an animal model
  publication-title: Acta Vet
  contributor:
    fullname: Todorović
– volume: 5
  start-page: 5
  year: 1984
  end-page: 10
  article-title: Biomaterial biocompatibility and the macrophage
  publication-title: Biomaterials
  contributor:
    fullname: Miller
– volume: 262
  start-page: 36
  year: 2014
  end-page: 55
  article-title: Macrophage heterogeneity in tissues: phenotypic diversity and functions
  publication-title: Immunological Rev
  contributor:
    fullname: Martinez Estrada
– volume: 3
  start-page: 511
  issue: 8
  year: 2014
  end-page: 529
  article-title: Wound dressings and comparative effectiveness data
  publication-title: Adv Wound Care
  contributor:
    fullname: Tomaselli
– volume: 17
  start-page: 317
  year: 2015
  end-page: 349
  article-title: Biomaterial strategies for immunomodulation
  publication-title: Annu Rev Biomed Eng
  contributor:
    fullname: Irvine
– volume: 77
  start-page: 83
  year: 2019
  end-page: 96
  article-title: Kinetic models of swelling and thermal stability of silver/poly(vinyl alcohol)/chitosan/graphene hydrogels
  publication-title: J Ind Eng Chem
  contributor:
    fullname: Perić-Grujić
– volume: 1
  start-page: R1
  issue: 1
  year: 2006
  end-page: R9
  article-title: A review on macrophage responses to biomaterials
  publication-title: Biomed Mater (Bristol, England)
  contributor:
    fullname: Triffitt
– volume: 18
  start-page: 395
  year: 1984
  end-page: 401
  article-title: Some aspects of macrophage behavior at the implant interface
  publication-title: J Biomed Mater Res
  contributor:
    fullname: Salthouse
– volume: 100
  start-page: 166
  year: 2014
  end-page: 178
  article-title: Antimicrobial wound dressing nanofiber mats from multicomponent (chitosan/silver-NPs/polyvinyl alcohol) systems
  publication-title: Carbohydr Polym
  contributor:
    fullname: Rojas
– volume: 19
  start-page: 2880
  issue: 7
  year: 2018
  end-page: 2888
  article-title: Zwitterionic PEG-PC hydrogels modulate the foreign body response in a modulus-dependent manner
  publication-title: Biomacromolecules
  contributor:
    fullname: Peyton
– volume: 7
  start-page: S379
  issue: Suppl 4
  year: 2010
  end-page: S391
  article-title: Twenty-first century challenges for biomaterials
  publication-title: J R Soc Interf
  contributor:
    fullname: Thompson
– volume: 8
  start-page: 4131
  year: 2013
  end-page: 4145
  article-title: Silver nanoparticle/chitosan oligosaccharide/poly(vinyl alcohol) nanofibers as wound dressings: a preclinical study
  publication-title: Int J Nanomed
  contributor:
    fullname: Yu
– volume: 3
  start-page: 73
  issue: 2
  year: 2016
  end-page: 77
  article-title: Future challenges in thein vitroandin vivoevaluation of biomaterial biocompatibility
  publication-title: Regen Biomater
  contributor:
    fullname: Anderson
– volume: 153
  start-page: 592
  year: 2016
  end-page: 599
  article-title: Enhanced mechanical, thermal and antimicrobial properties of poly(vinyl alcohol)/graphene oxide/starch/silver nanocomposites films
  publication-title: Carbohydr Polym
  contributor:
    fullname: Riaz
– volume: 23
  start-page: P384
  year: 2004
  article-title: Comprehensive scoring system for biomaterial implants, American College of Toxicology Presentation
  publication-title: Int J Toxicol
  contributor:
    fullname: Muench
– volume: 38
  start-page: 705
  year: 2007
  end-page: 724
  article-title: [Porous polyvinyl alcohol hydrogel composite prepared and studied initially for biocompatibility]
  publication-title: Sichuan da Xue Xue Bao Yi Xue Ban
  contributor:
    fullname: Yang
– volume: 30
  start-page: 773
  year: 2014
  end-page: 788
  article-title: Non-cytotoxic silver nanoparticle-polyvinyl alcohol hydrogels with anti-biofilm activity: designed as coatings for endotracheal tube materials
  publication-title: Biofouling
  contributor:
    fullname: Lee
– volume: 60
  start-page: 487
  year: 2002
  end-page: 496
  article-title: Protein and surface effects on monocyte and macrophage adhesion, maturation, and survival
  publication-title: J Biomed Mater Res
  contributor:
    fullname: Anderson
– volume: 84
  start-page: 229
  issue: 2
  year: 2000
  end-page: 236
  article-title: Cytotoxicity of dental alloys, metals, and ceramics assessed by millipore filter, agar overlay, and MTT tests
  publication-title: J Prosthet Dent
  contributor:
    fullname: Dahl
– volume: 98
  start-page: 953
  year: 2015
  end-page: 962
  article-title: Macrophage responses to implants: prospects for personalized medicine
  publication-title: J Leukoc Biol
  contributor:
    fullname: Riabov
– volume: 2
  start-page: 16
  year: 2002
  end-page: 23
  article-title: The biology of the macrophage
  publication-title: Macrophage
  contributor:
    fullname: Burke
– volume: 20
  start-page: 86
  year: 2008
  end-page: 100
  article-title: Foreign body reaction to biomaterials
  publication-title: Semin Immunol
  contributor:
    fullname: Chang
– volume: 14
  start-page: 671
  year: 2003
  end-page: 675
  article-title: Effects of adsorbed heat labile serum proteins and fibrinogen on adhesion and apoptosis of monocytes/macrophages on biomaterials
  publication-title: J Mater Sci Mater Med
  contributor:
    fullname: Anderson
– volume: 34
  start-page: 250
  year: 2016
  end-page: 257
  article-title: The effect of graphene loading on mechanical, thermal and biological properties of poly(vinyl alcohol)/graphene nanocomposites
  publication-title: J Ind Eng Chem
  contributor:
    fullname: Mitrić
– volume: 45
  start-page: 148
  year: 1999
  end-page: 154
  article-title: Spatial regulation and surface chemistry control of monocyte/macrophage adhesion and foreign body giant cell formation by photochemically micropatterned surfaces
  publication-title: J Biomed Mater Res
  contributor:
    fullname: Nakayama
– volume: 5
  start-page: 233
  year: 2013
  end-page: 249
  article-title: Nanotechnology for implantable sensors: carbon nanotubes and graphene in medicine
  publication-title: Wiley Interdiscip Rev Nanomed Nanobiotechnol
  contributor:
    fullname: Monty
– volume: 165
  start-page: 107821
  year: 2021
  article-title: Alter macrophage adhesion and modulate their response on hydrophobically modified hydrogels
  publication-title: Biochem Eng J
  contributor:
    fullname: Bartlett
– volume: 121
  start-page: 109257
  year: 2019
  article-title: Chitosan-based hydrogel wound dressings with electrochemically incorporated silver nanoparticles – in vitro study
  publication-title: Eur Polym J
  contributor:
    fullname: Radetić
– volume: 71A
  start-page: 439
  year: 2004
  end-page: 448
  article-title: Surface chemistry mediates adhesive structure, cytoskeletal organization, and fusion of macrophages
  publication-title: J Biomed Mater Res
  contributor:
    fullname: Hiltner
– volume: 74A
  start-page: 222
  year: 2005
  end-page: 229
  article-title: Lymphocytes and the foreign body response: lymphocyte enhancement of macrophage adhesion and fusion
  publication-title: J Biomed Mater Res A
  contributor:
    fullname: Colton
– volume: 105
  start-page: 176
  year: 2016
  end-page: 189
  article-title: Antibacterial applications of graphene-based nanomaterials: recent achievements and challenges
  publication-title: Adv Drug Deliv Rev
  contributor:
    fullname: Qu
– volume: 4
  start-page: 20130049
  year: 2014
  article-title: Mechanical properties and in vitro characterization of polyvinyl alcohol-nano-silver hydrogel wound dressings
  publication-title: Int Focus
  contributor:
    fullname: Quilty
– volume: 10
  start-page: 579
  year: 1999
  end-page: 588
  article-title: Monocyte, macrophage and foreign body giant cell interactions with molecularly engineered surfaces
  publication-title: J Mater Sci Mater Med
  contributor:
    fullname: McNally
– volume: 140
  start-page: 99
  year: 2018
  end-page: 107
  article-title: In situ electrochemical synthesis of silver-doped poly(vinyl alcohol)/graphene composite hydrogels and their physico-chemical and thermal properties
  publication-title: Compos B Eng
  contributor:
    fullname: Nešović
– volume: 104
  start-page: 26
  year: 2016
  end-page: 34
  article-title: Biological activity of electrochemically synthesized silver doped polyvinyl alcohol/graphene composite hydrogel discs for biomedical applications
  publication-title: Compos B Eng
  contributor:
    fullname: Janković
– volume: 11
  start-page: 3246
  issue: 6
  year: 2019
  end-page: 3260
  article-title: The application of graphene-based biomaterials in biomedicine
  publication-title: Am J Transl Res
  contributor:
    fullname: He
– volume: 79
  start-page: 237
  year: 2017
  end-page: 244
  article-title: Physicochemical properties of liposomal modifiers that shift macrophage phenotype
  publication-title: Mater Sci Eng C
  contributor:
    fullname: Bratlie
– volume: 21
  start-page: 199
  year: 2006
  end-page: 203
  article-title: In vitro studies-how good are they at replacing in vivo studies for measurement of skin absorption?
  publication-title: Environ Toxicol Pharmacol
  contributor:
    fullname: Williams
– volume: 18
  start-page: 192
  issue: 1
  year: 2016
  end-page: 203
  article-title: Foreign body reaction to biomaterials: on mechanisms for buildup and breakdown of osseointegration
  publication-title: Clin Implant Dent Relat Res
  contributor:
    fullname: Tengvall
– volume: 7
  start-page: 1
  year: 2018
  end-page: 21
  article-title: Synthetic polymeric biomaterials for wound healing: a review
  publication-title: Prog Biomater
  contributor:
    fullname: Barakullah
– volume: 23
  start-page: 4185
  year: 2002
  end-page: 4192
  article-title: The effect of microgeometry, implant thickness and polyurethane chemistry on the foreign body response to subcutaneous implants
  publication-title: Biomaterials
  contributor:
    fullname: Tiekotter
– volume: 253
  start-page: 265
  year: 1998
  end-page: 272
  article-title: IL-13 as well as IL-4 induces monocytes/macrophages and a monoblastic cell line (UG3) to differentiate into multinucleated giant cells in the presence of M-CSF
  publication-title: Biochem Biophys Res Commun
  contributor:
    fullname: Sasaki
– volume: 27
  start-page: 7563
  issue: 46
  year: 2015
  end-page: 7582
  article-title: Graphite oxide to graphene. biomaterials to bionics
  publication-title: Adv Mater
  contributor:
    fullname: Wallace
– volume: 31
  start-page: 9192
  year: 2010
  end-page: 9201
  article-title: The relationship between collagen scaffold cross-linking agents and neutrophils in the foreign body reaction
  publication-title: Biomaterials
  contributor:
    fullname: van Luyn
– volume: 2
  start-page: 217
  issue: 1
  year: 2019
  end-page: 225
  article-title: How cross-linking mechanisms of methacrylated gellan gum hydrogels alter macrophage phenotype
  publication-title: ACS Appl Bio Mater
  contributor:
    fullname: Bratlie
– volume: 6
  start-page: 13
  year: 2014
  article-title: The M1 and M2 paradigm of macrophage activation: time for reassessment
  publication-title: F1000prime Rep
  contributor:
    fullname: Gordon
– volume: 57
  start-page: 336
  year: 2001
  end-page: 345
  article-title: The effects of surface chemistry and adsorbed proteins on monocyte/macrophage adhesion to chemically modified polystyrene surfaces
  publication-title: J Biomed Mater Res
  contributor:
    fullname: Horbett
– volume: 26
  start-page: 2933
  year: 2005
  end-page: 2945
  article-title: Gene expression clustering using self-organizing maps: analysis of the macrophage response to particulate biomaterials
  publication-title: Biomaterials
  contributor:
    fullname: Rubash
– volume: 85
  start-page: 617
  issue: 4
  year: 2009
  end-page: 626
  article-title: Macrophage fusion, giant cell formation, and the foreign body response require matrix metalloproteinase 9
  publication-title: J Leukoc Biol
  contributor:
    fullname: Meznarich
– volume: 28
  start-page: 73
  year: 1994
  end-page: 79
  article-title: Theoretical analysis ofin vivo macrophage adhesion and foreign body gaint cell formation on polydimethylsiloxane, low density polyethylene, and polyetherurethanes
  publication-title: J Biomed Mater Res
  contributor:
    fullname: Hiltner
– volume: 24
  start-page: 3933
  year: 2014
  end-page: 3943
  article-title: A novel wound dressing based on Ag/graphene polymer hydrogel: effectively kill bacteria and accelerate wound healing
  publication-title: Adv Funct Mater
  contributor:
    fullname: Wang
– volume: 90
  start-page: 207
  issue: 2
  year: 2017
  end-page: 213
  article-title: Graphene based composite hydrogel for biomedical applications
  publication-title: Croat Chem Acta
  contributor:
    fullname: Rhee
– volume: 105
  start-page: 362
  year: 2016
  end-page: 376
  article-title: The controversial antibacterial activity of graphene-based materials
  publication-title: Carbon
  contributor:
    fullname: Zou
– volume: 32
  start-page: 1197
  issue: 9
  year: 2018
  end-page: 1211
  article-title: Comparative in vivo evaluation of novel formulations based on alginate and silver nanoparticles for wound treatments
  publication-title: J Biomater Appl
  contributor:
    fullname: Jancic
– volume: 28
  start-page: 81
  year: 1994
  end-page: 90
  article-title: Macrophage/particle interactions: effect of size, composition and surface area
  publication-title: J Biomed Mater Res
  contributor:
    fullname: Black
– volume: 354
  start-page: 240
  year: 2015
  end-page: 250
  article-title: Control of macrophage dynamics as a potential therapeutic approach for clinical disorders involving chronic inflammation
  publication-title: J Pharmacol Exp Ther
  contributor:
    fullname: Hattori
– volume: 3
  start-page: 107
  year: 2016
  end-page: 110
  article-title: A pore way to heal and regenerate: 21st century thinking on biocompatibility
  publication-title: Regen Biomater
  contributor:
    fullname: Ratner
– volume: 34
  start-page: 54
  year: 2014
  end-page: 61
  article-title: Poly(vinyl alcohol)/cellulose nanowhiskers nanocomposite hydrogels for potential wound dressings
  publication-title: Mater Sci Eng C
  contributor:
    fullname: Ponce
– volume: 58
  start-page: 381
  year: 2008
  end-page: 393
  article-title: A tissue-implant reaction associated with subcutaneous implantation of alpha-tricalcium phosphate, dental ceramic, and hydroxyapatite bioceramics in rats
  publication-title: Acta Vet
  contributor:
    fullname: Markovic
– volume: 59
  start-page: 243
  year: 2009
  end-page: 253
  article-title: Histological and immunohistochemical evaluations of rat soft tissue response to bioceramical implants
  publication-title: Acta Vet
  contributor:
    fullname: Marinković
– volume: 8
  start-page: 5671
  year: 2015
  end-page: 5701
  article-title: Macrophages, foreign body giant cells and their response to implantable biomaterials
  publication-title: Materials
  contributor:
    fullname: Barzilay
– volume: 32
  start-page: 2048
  year: 2012
  end-page: 2051
  article-title: Polyvinyl alcohol/silver nanoparticles (PVA/AgNps) as a model for testing the biological activity of hybrid materials with included silver nanoparticles
  publication-title: Mater Sci Eng C
  contributor:
    fullname: Kantardjiev
– volume: 30
  start-page: 5897
  year: 2009
  end-page: 5909
  article-title: On the nature of biomaterials
  publication-title: Biomaterials
  contributor:
    fullname: Williams
– volume: 12
  start-page: 1955
  year: 2006
  end-page: 1970
  article-title: Cellular and molecular dynamics in the foreign body reaction
  publication-title: Tissue Eng
  contributor:
    fullname: Luyn
– volume: 5
  start-page: 469
  issue: 3
  year: 2010
  end-page: 484
  article-title: Engineering hydrogels as extracellular matrix mimics
  publication-title: Nanomedicine
  contributor:
    fullname: Zhang
– volume: 8
  start-page: 217
  year: 2017
  end-page: 233
  article-title: A review on polymeric hydrogel membranes for wound dressing applications: PVA-based hydrogel dressings
  publication-title: J Adv Res
  contributor:
    fullname: Chen
– volume: 5
  start-page: 161
  year: 2001
  end-page: 162
  article-title: Biomaterials: surface interactions
  publication-title: Curr Opin Solid State Mater Sci
  contributor:
    fullname: Shoichet
– volume: 34
  start-page: 599
  issue: 3
  year: 2017
  end-page: 610
  article-title: Chronic wound healing: a review of current management and treatments
  publication-title: Adv Ther
  contributor:
    fullname: Ceilley
– volume: 11
  start-page: 1
  issue: 1
  year: 2019
  end-page: 12
  article-title: An injectable self-healing coordinative hydrogel with antibacterial and angiogenic properties for diabetic skin wound repair
  publication-title: NPG Asia Mat
  contributor:
    fullname: Zhao
– start-page: 1
  year: 2021
  end-page: 16
  article-title: Animal models in bicompatibility assessments of implants in soft and hard tissues
  publication-title: Vet Glasnik
  contributor:
    fullname: Gajdov
– volume: 68
  start-page: 321
  year: 2018
  end-page: 339
  article-title: In vivo investigation of soft tissue response of novel silver/poly(vinyl alcohol)/graphene and silver/poly(vinyl alcohol)/chitosan/graphene hydrogels aimed for medical applications–the first experience
  publication-title: Acta Vet
  contributor:
    fullname: Todorović
– ident: bibr61-08853282211046119
  doi: 10.1002/jbm.820280110
– ident: bibr65-08853282211046119
  doi: 10.1093/rb/rbw001
– ident: bibr13-08853282211046119
  doi: 10.2298/AVB0903243M
– ident: bibr30-08853282211046119
  doi: 10.1002/adfm.201304202
– ident: bibr53-08853282211046119
  doi: 10.1067/mpr.2000.107227
– volume: 8
  start-page: 4131
  year: 2013
  ident: bibr27-08853282211046119
  publication-title: Int J Nanomed
  contributor:
    fullname: Li C
– ident: bibr54-08853282211046119
  doi: 10.2478/acve-2021-0025
– ident: bibr67-08853282211046119
  doi: 10.1111/imr.12223
– ident: bibr34-08853282211046119
  doi: 10.1016/j.compositesb.2017.12.017
– ident: bibr12-08853282211046119
  doi: 10.5562/cca3133
– ident: bibr22-08853282211046119
  doi: 10.1007/978-88-470-1104-5_5
– ident: bibr51-08853282211046119
  doi: 10.1016/j.addr.2016.04.009
– ident: bibr63-08853282211046119
  doi: 10.1002/1097-4636(20011205)57:3<336::AID-JBM1176>3.0.CO;2-E
– ident: bibr17-08853282211046119
  doi: 10.1016/0142-9612(84)90060-7
– volume: 38
  start-page: 705
  year: 2007
  ident: bibr5-08853282211046119
  publication-title: Sichuan da Xue Xue Bao Yi Xue Ban
  contributor:
    fullname: Wu JQ
– ident: bibr21-08853282211046119
  doi: 10.1089/wound.2012.0401
– volume: 2
  start-page: 16
  year: 2002
  ident: bibr56-08853282211046119
  publication-title: Macrophage
  contributor:
    fullname: Ross J
– ident: bibr58-08853282211046119
  doi: 10.1016/S1359-0286(01)00012-2
– volume: 4
  start-page: 20130049
  year: 2014
  ident: bibr28-08853282211046119
  publication-title: Int Focus
  contributor:
    fullname: Oliviera RN
– ident: bibr19-08853282211046119
  doi: 10.1016/j.jare.2017.01.005
– ident: bibr24-08853282211046119
  doi: 10.1016/j.carbpol.2012.12.043
– volume: 23
  start-page: P384
  year: 2004
  ident: bibr1-08853282211046119
  publication-title: Int J Toxicol
  contributor:
    fullname: Upman PJ
– ident: bibr20-08853282211046119
  doi: 10.1007/s40204-018-0083-4
– ident: bibr49-08853282211046119
  doi: 10.1002/wnan.1213
– ident: bibr72-08853282211046119
  doi: 10.1021/acs.biomac.8b00444
– volume: 11
  start-page: 3246
  issue: 6
  year: 2019
  ident: bibr38-08853282211046119
  publication-title: Am J Transl Res
  contributor:
    fullname: Han S
– ident: bibr68-08853282211046119
  doi: 10.1189/jlb.5VMR0415-166R
– ident: bibr44-08853282211046119
  doi: 10.1006/bbrc.1998.9702
– ident: bibr52-08853282211046119
  doi: 10.1146/annurev-bioeng-071813-104814
– ident: bibr75-08853282211046119
  doi: 10.1023/A:1008976531592
– ident: bibr7-08853282211046119
  doi: 10.1093/rb/rbw006
– ident: bibr69-08853282211046119
  doi: 10.1124/jpet.115.225540
– ident: bibr71-08853282211046119
  doi: 10.1016/j.msec.2017.05.032
– ident: bibr73-08853282211046119
  doi: 10.1021/acsabm.8b00562
– ident: bibr23-08853282211046119
  doi: 10.1016/j.msec.2013.10.006
– ident: bibr4-08853282211046119
  doi: 10.1016/j.jiec.2015.11.016
– ident: bibr50-08853282211046119
  doi: 10.1002/adma.201500411
– ident: bibr36-08853282211046119
  doi: 10.1016/S0142-9612(02)00160-6
– ident: bibr37-08853282211046119
  doi: 10.3390/polym7020186
– ident: bibr43-08853282211046119
  doi: 10.1002/jbm.a.30165
– ident: bibr55-08853282211046119
  doi: 10.1002/jbm.10043
– ident: bibr11-08853282211046119
  doi: 10.2478/acve-2018-0027
– ident: bibr41-08853282211046119
  doi: 10.1016/j.smim.2007.11.004
– ident: bibr31-08853282211046119
  doi: 10.1016/j.jiec.2019.04.022
– ident: bibr14-08853282211046119
  doi: 10.1177/0885328218759564
– ident: bibr8-08853282211046119
  doi: 10.1016/j.etap.2005.07.009
– ident: bibr47-08853282211046119
  doi: 10.1088/1748-6041/1/1/R01
– ident: bibr48-08853282211046119
  doi: 10.1189/jlb.1008588
– ident: bibr42-08853282211046119
  doi: 10.1016/j.biomaterials.2010.08.049
– volume-title: Proceedings of a Consensus Conference of the European Society for Biomaterials
  year: 2004
  ident: bibr2-08853282211046119
  contributor:
    fullname: Williams DF
– ident: bibr18-08853282211046119
  doi: 10.1111/cid.12274
– ident: bibr16-08853282211046119
  doi: 10.2298/VETGL210322005P
– ident: bibr62-08853282211046119
  doi: 10.1016/j.biomaterials.2004.06.034
– ident: bibr35-08853282211046119
  doi: 10.1016/j.biomaterials.2009.07.027
– ident: bibr25-08853282211046119
  doi: 10.1016/j.msec.2012.05.016
– ident: bibr45-08853282211046119
  doi: 10.1023/A:1024951330265
– ident: bibr9-08853282211046119
  doi: 10.1016/j.eurpolymj.2019.109257
– ident: bibr39-08853282211046119
  doi: 10.3390/ma8095269
– ident: bibr57-08853282211046119
  doi: 10.1002/(SICI)1097-4636(199905)45:2<148::AID-JBM10>3.0.CO;2-U
– ident: bibr15-08853282211046119
  doi: 10.2298/AVB0804381S
– ident: bibr6-08853282211046119
  doi: 10.1007/978-88-470-1104-5_1
– volume: 7
  start-page: S379
  issue: 4
  year: 2010
  ident: bibr46-08853282211046119
  publication-title: J R Soc Interf
  contributor:
    fullname: Hench LL
– ident: bibr10-08853282211046119
  doi: 10.1016/j.compositesb.2016.08.024
– ident: bibr33-08853282211046119
  doi: 10.1016/j.carbon.2016.04.046
– ident: bibr32-08853282211046119
  doi: 10.1016/j.carbpol.2016.08.026
– ident: bibr64-08853282211046119
  doi: 10.1002/jbm.a.30313
– ident: bibr3-08853282211046119
  doi: 10.2217/nnm.10.12
– ident: bibr59-08853282211046119
  doi: 10.1002/jbm.820180407
– ident: bibr66-08853282211046119
  doi: 10.12703/P6-13
– ident: bibr60-08853282211046119
  doi: 10.1002/jbm.820280111
– ident: bibr74-08853282211046119
  doi: 10.1016/j.bej.2020.107821
– volume: 11
  start-page: 1
  issue: 1
  year: 2019
  ident: bibr29-08853282211046119
  publication-title: NPG Asia Mat
  doi: 10.1038/s41427-018-0100-z
  contributor:
    fullname: Chen H
– ident: bibr70-08853282211046119
  doi: 10.1007/s12325-017-0478-y
– ident: bibr40-08853282211046119
  doi: 10.1089/ten.2006.12.1955
– ident: bibr26-08853282211046119
  doi: 10.1080/08927014.2014.926475
SSID ssj0005946
Score 2.3333519
Snippet Biocompatibility of materials is one of the most important conditions for their successful application in tissue regeneration and repair. Cell-surface...
SourceID proquest
crossref
pubmed
sage
SourceType Aggregation Database
Index Database
Publisher
StartPage 1111
Title Macrophages, the main marker in biocompatibility evaluation of new hydrogels after subcutaneous implantation in rats
URI https://journals.sagepub.com/doi/full/10.1177/08853282211046119
https://www.ncbi.nlm.nih.gov/pubmed/34607494
https://search.proquest.com/docview/2579378435
Volume 36
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwvV1JS8NAFH5Ye9GD-1I3RhAEMbZJE5ucRFzoRREX0FPIzKRatIk0yaH_3u9lsa7gyUsIIcz25r33zbyNaKenJZSOzfVddMewpWoZUMPacDgXluOpnswtpt2bzuW9e3rGaXLiKhamXMHkgN2qMKJcWDN38210szQyNsEaTpsdIE02UZqmd5SlA7-47q6qavAXtk9nAzZtK3aIHBlVeFuN6pw5DyxRP76-unkYe4V4RWwPOjC4h9IQ-mOnn1XZN3z6yTcsV1fns_8-0TmaKZGtOC624jxNhNECTX_Id7hI6UXAFcOeMJZkXwB6ikHQj_AYPodDgTfZj3On-LTw2R2JcTJyEfcEjgDiaaSH8SM0usjLm4skkyoDwg3jLBH9wetLUARTRdwetneyRHfnZ7cnXaMs-2AoHJdTw3IUpIJ0zcCBgNCBxGcAM-latlYKAifEmnSUcmwLWM9sacjztiXNQ-0A3EFkLdNkFEfhKgm73VLS7rUV2sFB2Q0sy9M4UHWkp23ltRq0V1HQfy2ye_hmlQD969I3aLuisQ8eZMNKMTkfYg8oz8VoGrRSEP-9OfABUJpnN2iXKe1XdP-9n7U__7lOUxZHY-Q3Qhs0mQ6zcJNqic62yn39BsabChk
link.rule.ids 315,782,786,27926,27933,27934,44981,45369
linkProvider SAGE Publications
linkToHtml http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1ZS8QwEB50fVAfvI_1jCAIYmXbprutb-LBigfiAfpUmqSri9ou2_Zh_71fengLgi-llGaaZCYzXzpHiDY7SsDocH2-i2oZXMiGATOsDEfXwnI82RG5x7R93bq4cw-PdJmcvSoXppzBZFeHVaFHubJ-W926UpILA6NjH03tnTR1xc8R7thNSPTI_tXl9f17gIdXpOmggaFblD7NH4l8tkrfoOanMK_c8hxP_qfPUzRR4k22XwjINA2F0QyNf6hCOEvpeaDP8XoE2WSHARCyl6Ab4dJ_CvsMd6Ib56HqaRFJO2DvJcJZ3GEA5uxxoPrxA-wsyw8dZ0kmZAbcGcZZwrovveegSHGKND0IXTJHt8dHNwdtozyMwZDYxKaG5UisVeGagYNlqwKBx4BLwrW4khJqIMQYW1I63AICMxsKWta2hNlUDiAXFMk81aI4CheJcbshBe_YEnSwfXUDy_IUtjkt4SkuvUadtitm-L2i5oZvVmXJv05lnTYqdvlYGdrdUQzOhzIC9nLRmzotFHx8IwfpBHbyeJ22NNP8ioW_f2fpz2-u02j75vzMPzu5OF2mMUvnS-T_bFaolvazcJWGE5WtleL6CifJ4fM
linkToPdf http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1ZS8QwEB48QPTB-1jPCIIgVrfd1G1fBHFdFHVZPECfSpO0uqjtst0--O_90sP1BMGXUkozTTKZmS-dI0RboRIwOlyf76LqBheyasAMK8PWtbBsV4Yi85ieXtdbd07jRJfJOSxzYYoZTPZ0WBV6lClrLd1dFe4XPsZ9SIZd0_GPpvZQmrrq5yjnrgPBHD26al_fD4I83DxVBw0M3aLwa_5I5LNl-gY3P4V6ZdanOfXffk_TZIE72VG-UGZoKIhmaeJDNcI56l_6-jyvR5BOdhmAIXvxOxEuvaegx3AnOnEWst7PI2pf2aBUOItDBoDOHl9VL36AvWXZ4eMsSYVMgT-DOE1Y56X77OepTpGmh8WXzNNt8-Tm-NQoDmUwJDazfcOyJWRWOKZvQ3yVL_AYsEk4FldSQh0EGGNdSptbQGJmVUHb1ixhHigb0AsKZYFGojgKlojxWlUKHtYk6GAb6_iW5Spsd-rCVVy61QrtlAzxunntDc8sy5N_ncoKbZYs8yAh2u2RD86DUgIGc9CbCi3mvHwnh1UKDOXyCm1rxnklG3__zvKf39ygsXaj6V2ctc5XaNzSaRPZr5tVGun30mCNhhOVrhcr9g3SJuRw
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Macrophages%2C+the+main+marker+in+biocompatibility+evaluation+of+new+hydrogels+after+subcutaneous+implantation+in+rats&rft.jtitle=Journal+of+biomaterials+applications&rft.au=Lu%C5%BEaji%C4%87+Bo%C5%BEinovski%2C+Tijana&rft.au=Todorovi%C4%87%2C+Vera&rft.au=Milo%C5%A1evi%C4%87%2C+Ivan&rft.au=Proki%C4%87%2C+Bogomir+Bolka&rft.date=2022-01-01&rft.eissn=1530-8022&rft.volume=36&rft.issue=6&rft.spage=1111&rft.epage=1125&rft_id=info:doi/10.1177%2F08853282211046119&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0885-3282&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0885-3282&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0885-3282&client=summon