Hormone receptors and enzymatic activities in human endometrial adenocarcinoma

• Published in: Annals of the New York Academy of Sciences Vol. 595; p. 334
• Main Authors: Dell'Acqua, S, De Cicco Nardone, F, Benedetto, M T, Iacobelli, S, Rossiello, F, Bongiorno, M, Margariti, P A
• Format: Journal Article
• Language: English
• Published: United States 01-01-1990
• Subjects: 17-Hydroxysteroid Dehydrogenases - metabolism; Adenocarcinoma - physiopathology; Cell Nucleus - metabolism; Creatine Kinase - metabolism; Cytosol - metabolism; Endometrium - physiopathology; Female; Humans; Interferon Type I - pharmacology; Medroxyprogesterone - analogs & derivatives; Medroxyprogesterone - therapeutic use; Medroxyprogesterone Acetate; Menstruation; Receptors, Estrogen - physiology; Receptors, Progesterone - physiology; Tamoxifen - therapeutic use; Tumor Cells, Cultured; Uterine Neoplasms - physiopathology
• ISSN: 0077-8923
• DOI: 10.1111/j.1749-6632.1990.tb34307.x

The hormone sensitivity of endometrial carcinoma is related to the presence of steroid hormone receptors. The determination of progesterone receptors has been proposed in order to predict clinical prognosis and to aid treatment selection. The integrity of the hormone receptor system and postreceptoral events in tumors is essential to endocrine therapy response. Nevertheless, although hormone receptors are present in a large number of endometrial carcinomas, only 30% of cases respond to hormone therapy. In some neoplasms the receptors can be present, but not functioning, or else neoplastic transformation could have induced alterations in processes after hormone-receptor interaction.