Fluorouracil-Based Chemotherapy in Patients with Gastrointestinal Malignancies: Influence of Nutritional Folate Status on Toxicity

This study aimed to prospectively evaluate the potential influence of folate status on the toxicity induced by 5-fluorouracil (5-FU)-based chemotherapy in patients with gastrointestinal tumors. 105 patients with colorectal, pancreatic or gastric cancer were entered into the study. Treatment regimens...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of chemotherapy (Florence) Vol. 19; no. 6; pp. 744 - 749
Main Authors:	Alvarez-Cabellos, R., Garcia-Carbonero, R., Garcia-Lacalle, C., Gomez, P., Tercero, A., Sanchez, D., Paz-Ares, L.
Format:	Journal Article
Language:	English
Published:	Firenze Taylor & Francis 01-12-2007 EIFT
Subjects:	Adult Aged Antibiotics. Antiinfectious agents. Antiparasitic agents Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Cisplatin - administration & dosage Female Fluoropyrimidines Fluorouracil - administration & dosage Fluorouracil - adverse effects folate Folic Acid - blood Gastroenterology. Liver. Pancreas. Abdomen gastrointestinal cancer Gastrointestinal Neoplasms - drug therapy homocysteine Homocysteine - blood Humans Male Medical sciences Middle Aged Pharmacology. Drug treatments Stomach. Duodenum. Small intestine. Colon. Rectum. Anus toxicity Tumors Vitamin B 12 - blood Vitamin B 12 - metabolism vitamin B12 Antineoplastic agent Toxicity Vitamin Folate Homocystein Intestinal disease vitamin B12 Nutritional status Gastric disease Fluorouracil Human homocysteine Thiol Enzyme Gastrointestinal cancer Transferases Fluoropyrimidine derivatives Enzyme inhibitor Malignant tumor Thymidylate synthase Cyanocobalamin Sulfur containing aminoacid Fluoropyrimidines Chemotherapy Treatment Antimetabolic Methyltransferases Pyrimidine derivatives Digestive diseases Cancer
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!