Impact of race on heart rate characteristics monitoring in very low birth weight infants

• Published in: Pediatric research Vol. 94; no. 2; pp. 575 - 580
• Main Authors: Sullivan, Brynne A., Hochheimer, Camille J., Chernyavskiy, Pavel, King, William E., Fairchild, Karen D.
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01-08-2023; Nature Publishing Group
• Subjects: Birth Weight; Clinical Research Article; Gestational Age; Heart rate; Heart Rate - physiology; Humans; Infant; Infant, Newborn; Infant, Very Low Birth Weight; Length of stay; Medicine; Medicine & Public Health; Mortality; Pediatric Surgery; Pediatrics; Predictive analytics; Sepsis; Sepsis - diagnosis; Ventilators
• ISSN: 0031-3998; 1530-0447
• DOI: 10.1038/s41390-023-02470-z

Background
A multicenter RCT showed that displaying a heart rate characteristics index (HRCi) predicting late-onset sepsis reduced mortality for VLBW infants. We aimed to assess whether HRCi display had a differential impact for Black versus White infants.
Methods
We performed secondary data analysis of Black and White infants enrolled in the HeRO RCT. We evaluated the predictive performance of the HRCi for infants with Black or White maternal race. Using models adjusted for birth weight, we assessed outcomes and interventions for a race × randomization interaction.
Results
Among 2607 infants, Black infants had lower birth weight, gestational age, length of stay, and ventilator days, while sepsis and mortality were similar. The HRCi performed equally for sepsis prediction in Black and White infants. We found no differential effect of randomization by race on sepsis, mortality, antibiotic days, length of stay, or ventilator days. However, there was a differential randomization effect by race for blood cultures per patient: White RR 1.11 (95% CrI 1.04–1.18), Black RR 1.00 (0.93–1.07).
Conclusions
The HRCi performed similarly for sepsis prediction in Black and White infants. Randomization to HRCi display increased blood cultures in White but not in Black infants, while the impact on other outcomes or interventions was similar.
Impact
Predictive analytics, such as heart rate characteristics (HRC) monitoring for late-onset neonatal sepsis, should have equal impact among patients of different race. Infants with Black or White maternal race randomized to HRC display had similar outcomes, but randomization to the study arm increased a related clinical intervention, blood cultures, in White but not in Black infants.
This study provides evidence of a differential effect of predictive models on clinical care by race.
The work will promote consideration and analysis of equity in the implementation of predictive analytics.