Myosin in chromosome organisation and gene expression

Myosin in chromosome organisation and gene expression

The importance of myosin motor protein is well-characterised within the cytoplasm and cytoskeleton. However, mounting evidence on four nuclear myosins highlights the central role these proteins have in maintaining genomic stability and gene expression. This review focuses on each of their critical r...

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Bibliographic Details
Published in:Biochemical Society transactions Vol. 51; no. 3; p. 1023
Main Authors: Shahid-Fuente, Isabel W, Toseland, Christopher P
Format: Journal Article
Language:English
Published: England 28-06-2023
Subjects:
Animals
Cell Nucleus - metabolism
Chromatin - metabolism
Chromosomes - metabolism
Gene Expression
Humans
Myosins - genetics
nuclear myosin
myosin
transcription
gene expression
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Summary:The importance of myosin motor protein is well-characterised within the cytoplasm and cytoskeleton. However, mounting evidence on four nuclear myosins highlights the central role these proteins have in maintaining genomic stability and gene expression. This review focuses on each of their critical roles in chromatin structure, chromosome translocation, transcription regulation, and DNA damage repair in terms of maintaining chromosome and chromatin integrity.
ISSN:1470-8752
DOI:10.1042/BST20220939