Is Sonothrombolysis an Effective Stroke Treatment?
New therapeutic strategies under development aim to improve recanalization rates and clinical outcomes after ischemic stroke. One such approach is ultrasound (US)‐enhanced thrombolysis, or sonothrombolysis, which can improve thrombolytic drug actions and even intrinsic fibrinolysis. Although the mec...
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| Published in: | Journal of ultrasound in medicine Vol. 32; no. 7; pp. 1117 - 1123 |
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| Main Authors: | , , |
| Format: | Journal Article |
| Language: | English |
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England
American Institute of Ultrasound in Medicine
01-07-2013
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| Abstract | New therapeutic strategies under development aim to improve recanalization rates and clinical outcomes after ischemic stroke. One such approach is ultrasound (US)‐enhanced thrombolysis, or sonothrombolysis, which can improve thrombolytic drug actions and even intrinsic fibrinolysis. Although the mechanisms are not fully understood, it is postulated that thrombolysis enhancement is related to nonthermal mechanical effects of US. Recent results indicate that US with or without microbubbles may be effective in clot lysis of ischemic stroke even without additional thrombolytic drugs. Sonothrombolysis is a promising tool for treating acute ischemic stroke, but its efficacy, safety, and technical details have not been elucidated and proved yet in stroke treatment. |
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| AbstractList | New therapeutic strategies under development aim to improve recanalization rates and clinical outcomes after ischemic stroke. One such approach is ultrasound (US)-enhanced thrombolysis, or sonothrombolysis, which can improve thrombolytic drug actions and even intrinsic fibrinolysis. Although the mechanisms are not fully understood, it is postulated that thrombolysis enhancement is related to nonthermal mechanical effects of US. Recent results indicate that US with or without microbubbles may be effective in clot lysis of ischemic stroke even without additional thrombolytic drugs. Sonothrombolysis is a promising tool for treating acute ischemic stroke, but its efficacy, safety, and technical details have not been elucidated and proved yet in stroke treatment. |
| Author | Mijajlovic, Milija D. Covickovic-Sternic, Nadezda Pavlovic, Aleksandra M. |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23804334$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1002_adfm_201404354 crossref_primary_10_3389_fonc_2019_00600 crossref_primary_10_3389_fphys_2017_00818 crossref_primary_10_1016_j_jstrokecerebrovasdis_2016_07_052 crossref_primary_10_1016_j_jstrokecerebrovasdis_2017_01_023 crossref_primary_10_1161_STROKEAHA_119_026049 crossref_primary_10_6061_clinics_2019_e715 crossref_primary_10_1093_intimm_dxab073 crossref_primary_10_1016_j_compbiomed_2019_103508 crossref_primary_10_1155_2021_6664453 crossref_primary_10_1208_s12249_015_0287_z |
| Cites_doi | 10.1056/NEJMp048249 10.1212/01.WNL.0000154599.45969.D6 10.1161/01.STR.0000110219.67054.BF 10.1007/s11239-007-0044-6 10.1056/NEJMoa041175 10.1161/01.STR.0000199064.94588.39 10.1161/STROKEAHA.107.181486 10.1161/STROKEAHA.111.636332 10.1016/S1051-0443(92)72029-6 10.1148/radiol.2391042181 10.1161/01.STR.0000143321.37482.b3 10.1016/S1474-4422(03)00380-6 10.1182/blood.V91.6.2019 10.7863/jum.2012.31.11.1789 10.1007/978-94-011-5704-9 10.1161/01.STR.0000150503.10480.a7 10.1111/j.1747-4949.2008.00167.x 10.1161/STROKEAHA.107.487967 10.1161/01.STR.0000170707.86793.1a 10.1016/0002-8703(93)90741-Q 10.1161/01.CIR.92.5.1148 10.1159/000203127 10.1016/j.ultras.2007.11.008 10.1161/01.STR.0000082721.62796.09 10.1016/j.ultrasmedbio.2005.03.005 10.1121/1.400102 10.1056/NEJMoa0804656 10.1016/j.euje.2004.02.001 10.1161/STROKEAHA.109.563304 10.1161/01.CIR.86.4.1257 10.1161/01.CIR.98.10.1030 10.1016/S0720-048X(98)00057-6 10.1016/j.nurt.2007.05.012 10.1161/01.STR.0000237070.80133.1d 10.1161/01.CIR.94.4.775 10.1161/STROKEAHA.107.503870 10.1161/01.STR.0000182100.65262.46 10.1161/01.STR.0000206443.96112.d9 10.1055/s-0038-1657688 10.1002/ana.21723 |
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| Keywords | sonothrombolysis acute ischemic stroke safety efficacy mechanisms of action |
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| References | 1998; 27 2009; 66 1995; 92 2006; 37 2008; 39 1996; 94 1976; 3 1997 2005; 64 2004; 5 2008; 3 1993; 125 2006; 239 2010; 41 2009; 27 2012; 31 2003; 34 2007; 38 2004; 351 1990; 88 2004; 35 1997; 78 2003; 2 2008; 25 2008; 48 2005; 31 2008; 359 2007; 4 1998; 91 1992; 86 2005; 16 1998; 98 2012; 43 1992; 3 2005; 36 e_1_2_8_28_1 e_1_2_8_29_1 e_1_2_8_24_1 e_1_2_8_25_1 e_1_2_8_26_1 e_1_2_8_27_1 Siddiqi F (e_1_2_8_19_1) 1998; 91 Trübestein G (e_1_2_8_12_1) 1976; 3 e_1_2_8_3_1 e_1_2_8_2_1 e_1_2_8_5_1 e_1_2_8_4_1 e_1_2_8_7_1 e_1_2_8_6_1 e_1_2_8_9_1 e_1_2_8_8_1 e_1_2_8_20_1 e_1_2_8_43_1 e_1_2_8_21_1 e_1_2_8_42_1 e_1_2_8_22_1 e_1_2_8_23_1 e_1_2_8_40_1 e_1_2_8_17_1 e_1_2_8_18_1 e_1_2_8_39_1 e_1_2_8_13_1 e_1_2_8_36_1 e_1_2_8_14_1 e_1_2_8_35_1 e_1_2_8_15_1 e_1_2_8_38_1 e_1_2_8_16_1 e_1_2_8_37_1 Culp WC (e_1_2_8_41_1) 2005; 16 e_1_2_8_32_1 e_1_2_8_10_1 e_1_2_8_31_1 e_1_2_8_11_1 e_1_2_8_34_1 e_1_2_8_33_1 e_1_2_8_30_1 |
| References_xml | – volume: 351 start-page: 2170 year: 2004 end-page: 2178 article-title: Ultrasound-enhanced systemic thrombolysis for acute ischemic stroke publication-title: N Engl J Med – volume: 92 start-page: 1148 year: 1995 end-page: 1150 article-title: Albumin microbubble echo-contrast material as an enhancer for ultrasound accelerated thrombolysis publication-title: Circulation – volume: 64 start-page: 1052 year: 2005 end-page: 1054 article-title: Sonothrombolysis in acute ischemic stroke for patients ineligible for rt-PA publication-title: Neurology – volume: 239 start-page: 86 year: 2006 end-page: 93 article-title: Pulsed high-intensity focused ultrasound enhances thrombolysis in an in vitro model publication-title: Radiology – volume: 31 start-page: 841 year: 2005 end-page: 847 article-title: Influence of ultrasound operating parameters on ultrasound-induced thrombolysis in vitro publication-title: Ultrasound Med Biol – volume: 36 start-page: 1441 year: 2005 end-page: 1446 article-title: Transcranial low-frequency ultrasound-mediated thrombolysis in brain ischemia: increased risk of hemorrhage with combined ultrasound and tissue plasminogen activator—results of a phase II clinical trial publication-title: Stroke – volume: 35 start-page: 2722 issue: suppl 1 year: 2004 end-page: 2725 article-title: Ultrasound identification and lysis of clots publication-title: Stroke – volume: 36 start-page: 124 year: 2005 end-page: 128 article-title: Can a commercial diagnostic ultrasound device accelerate thrombolysis? An in vitro skull model publication-title: Stroke – volume: 37 start-page: 1000 year: 2006 end-page: 1004 article-title: Temporal profile of recanalization after intravenous tissue plasminogen activator: selecting patients for rescue reperfusion techniques publication-title: Stroke – volume: 38 start-page: 2985 year: 2007 end-page: 2991 article-title: Facilities available in European hospitals treating stroke patients publication-title: Stroke – volume: 37 start-page: 2301 year: 2006 end-page: 2305 article-title: Tandem internal carotid artery/middle cerebral artery occlusion: an independent predictor of poor outcome after systemic thrombolysis publication-title: Stroke – volume: 43 start-page: 1706 year: 2012 end-page: 1710 article-title: Progress in sonothrombolysis for the treatment of stroke publication-title: Stroke – volume: 78 start-page: 1063 year: 1997 end-page: 1068 article-title: Ultrasound reversibly disaggregates fibrin fibers publication-title: Thromb Haemost – volume: 37 start-page: 425 year: 2006 end-page: 429 article-title: Microbubble administration accelerates clot lysis during continuous 2-MHz ultrasound monitoring in stroke patients treated with intravenous tissue plasminogen activator publication-title: Stroke – volume: 36 start-page: 2311 year: 2005 end-page: 2320 article-title: Extending reperfusion therapy for acute ischemic stroke: emerging pharmacological, mechanical, and imaging strategies publication-title: Stroke – volume: 3 start-page: 66 year: 2008 end-page: 72 article-title: Design of a PROspective multinational CLOTBUST collaboration on reperfusion therapies for stroke (CLOTBUST-PRO) publication-title: Int J Stroke – volume: 35 start-page: 486 year: 2004 end-page: 490 article-title: Differential pattern of tissue plasminogen activator–induced proximal middle cerebral artery recanalization among stroke subtypes publication-title: Stroke – volume: 88 start-page: 2059 year: 1990 end-page: 2069 article-title: Thresholds for transient cavitation produced by pulsed ultrasound in a controlled nuclei environment publication-title: J Acoust Soc Am – volume: 2 start-page: 283 year: 2003 end-page: 290 article-title: Ultrasound in the treatment of ischaemic stroke publication-title: Lancet Neurol – volume: 34 start-page: e109 year: 2003 end-page: e137 article-title: Trial design and reporting standards for intra-arterial cerebral thrombolysis for acute ischemic stroke publication-title: Stroke – volume: 3 start-page: 697s year: 1976 end-page: 698s article-title: Thrombolysis by ultrasound publication-title: Clin Sci Mol Med Suppl – volume: 66 start-page: 28 year: 2009 end-page: 38 article-title: Transcranial ultrasound in clinical sonothrombolysis (TUCSON) trial publication-title: Ann Neurol – volume: 125 start-page: 1564 year: 1993 end-page: 1569 article-title: Enhancement of thrombolysis by external ultrasound publication-title: Am Heart J – volume: 351 start-page: 2154 year: 2004 end-page: 2155 article-title: Ultrasound energy and the dissolution of thrombus publication-title: N Engl J Med – volume: 31 start-page: 1789 year: 2012 end-page: 1794 article-title: Changes in middle cerebral artery blood flow velocity during sonolysis using a diagnostic transcranial probe with a 2-MHz Doppler frequency in healthy volunteers publication-title: J Ultrasound Med – volume: 3 start-page: 299 year: 1992 end-page: 303 article-title: Enhancement of fibrinolysis with ultrasound energy publication-title: J Vasc Interv Radiol – volume: 27 start-page: S157 issue: suppl 2 year: 1998 end-page: S160 article-title: Ultrasound contrast agents: basic principles publication-title: Eur J Radiol – year: 1997 – volume: 48 start-page: 303 year: 2008 end-page: 311 article-title: Ultrasound enhanced thrombolysis in acute arterial ischemia publication-title: Ultrasonics – volume: 25 start-page: 219 year: 2008 end-page: 223 article-title: Microbubble potentiated transcranial duplex ultrasound enhances IV thrombolysis in acute stroke publication-title: J Thromb Thrombolysis – volume: 5 start-page: 245 year: 2004 end-page: 256 article-title: Microbubbles and ultrasound: from diagnosis to therapy publication-title: Eur J Echocardiogr – volume: 359 start-page: 1317 year: 2008 end-page: 1329 article-title: Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke publication-title: N Engl J Med – volume: 98 start-page: 1030 year: 1998 end-page: 1035 article-title: Enhancement of fibrinolysis with 40-kHz ultrasound publication-title: Circulation – volume: 91 start-page: 2019 year: 1998 end-page: 2025 article-title: Binding of tissue-plasminogen activator to fibrin: effect of ultrasound publication-title: Blood – volume: 41 start-page: 280 year: 2010 end-page: 287 article-title: Safety and efficacy of ultrasound-enhanced thrombolysis: a comprehensive review and meta-analysis of randomized and nonrandomized studies publication-title: Stroke – volume: 38 start-page: 1655 year: 2007 end-page: 1711 article-title: Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: the American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists publication-title: Stroke – volume: 86 start-page: 1257 year: 1992 end-page: 1264 article-title: Effect of ultrasound on tissue-type plasminogen activator–induced thrombolysis publication-title: Circulation – volume: 39 start-page: 1470 year: 2008 end-page: 1475 article-title: Sonothrombolysis with transcranial color-coded sonography and recombinant tissue-type plasminogen activator in acute middle cerebral artery main stem occlusion: results from a randomized study publication-title: Stroke – volume: 4 start-page: 420 year: 2007 end-page: 427 article-title: Ultrasound-enhanced thrombolysis in acute ischemic stroke: potential, failures, and safety publication-title: Neurotherapeutics – volume: 94 start-page: 775 year: 1996 end-page: 778 article-title: Transcutaneous ultrasound augments lysis of arterial thrombi in vivo publication-title: Circulation – volume: 27 start-page: 55 issue: suppl 2 year: 2009 end-page: 65 article-title: Microbubbles for thrombolysis of acute ischemic stroke publication-title: Cerebrovasc Dis – volume: 16 start-page: S36 issue: suppl year: 2005 article-title: Microbubble-augmented sonothrombolysis of occluded dialysis grafts: initial human experience [abstract] publication-title: J Vasc Interv Radiol – ident: e_1_2_8_17_1 doi: 10.1056/NEJMp048249 – ident: e_1_2_8_34_1 doi: 10.1212/01.WNL.0000154599.45969.D6 – ident: e_1_2_8_9_1 doi: 10.1161/01.STR.0000110219.67054.BF – ident: e_1_2_8_37_1 doi: 10.1007/s11239-007-0044-6 – ident: e_1_2_8_8_1 doi: 10.1056/NEJMoa041175 – ident: e_1_2_8_36_1 doi: 10.1161/01.STR.0000199064.94588.39 – ident: e_1_2_8_4_1 doi: 10.1161/STROKEAHA.107.181486 – ident: e_1_2_8_42_1 doi: 10.1161/STROKEAHA.111.636332 – ident: e_1_2_8_13_1 doi: 10.1016/S1051-0443(92)72029-6 – ident: e_1_2_8_22_1 doi: 10.1148/radiol.2391042181 – ident: e_1_2_8_7_1 doi: 10.1161/01.STR.0000143321.37482.b3 – ident: e_1_2_8_16_1 doi: 10.1016/S1474-4422(03)00380-6 – volume: 91 start-page: 2019 year: 1998 ident: e_1_2_8_19_1 article-title: Binding of tissue-plasminogen activator to fibrin: effect of ultrasound publication-title: Blood doi: 10.1182/blood.V91.6.2019 contributor: fullname: Siddiqi F – ident: e_1_2_8_43_1 doi: 10.7863/jum.2012.31.11.1789 – ident: e_1_2_8_33_1 doi: 10.1007/978-94-011-5704-9 – ident: e_1_2_8_24_1 doi: 10.1161/01.STR.0000150503.10480.a7 – ident: e_1_2_8_28_1 doi: 10.1111/j.1747-4949.2008.00167.x – ident: e_1_2_8_6_1 doi: 10.1161/STROKEAHA.107.487967 – ident: e_1_2_8_26_1 doi: 10.1161/01.STR.0000170707.86793.1a – volume: 3 start-page: 697s year: 1976 ident: e_1_2_8_12_1 article-title: Thrombolysis by ultrasound publication-title: Clin Sci Mol Med Suppl contributor: fullname: Trübestein G – ident: e_1_2_8_21_1 doi: 10.1016/0002-8703(93)90741-Q – ident: e_1_2_8_20_1 doi: 10.1161/01.CIR.92.5.1148 – ident: e_1_2_8_40_1 doi: 10.1159/000203127 – ident: e_1_2_8_27_1 doi: 10.1016/j.ultras.2007.11.008 – ident: e_1_2_8_3_1 doi: 10.1161/01.STR.0000082721.62796.09 – ident: e_1_2_8_23_1 doi: 10.1016/j.ultrasmedbio.2005.03.005 – ident: e_1_2_8_32_1 doi: 10.1121/1.400102 – ident: e_1_2_8_5_1 doi: 10.1056/NEJMoa0804656 – ident: e_1_2_8_35_1 doi: 10.1016/j.euje.2004.02.001 – ident: e_1_2_8_39_1 doi: 10.1161/STROKEAHA.109.563304 – ident: e_1_2_8_14_1 doi: 10.1161/01.CIR.86.4.1257 – ident: e_1_2_8_25_1 doi: 10.1161/01.CIR.98.10.1030 – ident: e_1_2_8_31_1 doi: 10.1016/S0720-048X(98)00057-6 – ident: e_1_2_8_30_1 doi: 10.1016/j.nurt.2007.05.012 – ident: e_1_2_8_10_1 doi: 10.1161/01.STR.0000237070.80133.1d – ident: e_1_2_8_15_1 doi: 10.1161/01.CIR.94.4.775 – ident: e_1_2_8_29_1 doi: 10.1161/STROKEAHA.107.503870 – ident: e_1_2_8_2_1 doi: 10.1161/01.STR.0000182100.65262.46 – ident: e_1_2_8_11_1 doi: 10.1161/01.STR.0000206443.96112.d9 – ident: e_1_2_8_18_1 doi: 10.1055/s-0038-1657688 – ident: e_1_2_8_38_1 doi: 10.1002/ana.21723 – volume: 16 start-page: S36 year: 2005 ident: e_1_2_8_41_1 article-title: Microbubble-augmented sonothrombolysis of occluded dialysis grafts: initial human experience [abstract] publication-title: J Vasc Interv Radiol contributor: fullname: Culp WC |
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| SubjectTerms | acute ischemic stroke efficacy Electroporation - methods Evidence-Based Medicine Fibrinolytic Agents - therapeutic use Humans mechanisms of action safety Sonication - methods sonothrombolysis Stroke - therapy Thrombolytic Therapy - methods Treatment Outcome Ultrasonic Therapy - methods |
| Title | Is Sonothrombolysis an Effective Stroke Treatment? |
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