Flumequine in the Goat: Pharmacokinetics after Intravenous and Intramuscular Administration

• Published in: Veterinary research communications Vol. 29; no. 8; pp. 689 - 698
• Main Authors: Villa, R, Cagnardi, P, Sonzogni, O, Carli, S
• Format: Journal Article
• Language: English
• Published: Netherlands Springer Nature B.V 01-11-2005
• Subjects: Animals; Anti-Infective Agents - administration & dosage; Anti-Infective Agents - pharmacokinetics; antimicrobial agents; bioavailability; Biological Availability; Cross-Over Studies; dosage; Female; flumequine; Fluoroquinolones - administration & dosage; Fluoroquinolones - pharmacokinetics; goats; Goats - metabolism; half life; Injections, Intramuscular - methods; Injections, Intramuscular - veterinary; Injections, Intravenous - methods; Injections, Intravenous - veterinary; intramuscular injection; intravenous injection; Metabolic Clearance Rate - drug effects; Metabolic Clearance Rate - physiology; pharmacokinetics; quinolones
• ISSN: 0165-7380; 1573-7446
• DOI: 10.1007/s11259-005-3867-7

The pharmacokinetics of flumequine, administered intravenously and intramuscularly at a single dose of 20 mg/kg, was investigated in healthy goats. After intravenous injection, flumequine distributed rapidly (t(1/2alpha) = 0.87 +/- 0.15 h) but was eliminated slowly (t(1/2beta) = 7.12 +/- 1.27 h); mean clearance (Cl) and volume of distribution (V(dss)) were 0.32 +/- 0.03 (L/(h.kg) and 1.22 +/- 029 (L/kg), respectively. After intramuscular administration, the peak serum concentration (C(max) = 7.40 +/- 0.5 microgram/ml) was reached in about 1.5 h (T(max)) and bioavailability was about 93%. Estimated flumequine serum levels following repeated intramuscular administration of the aqueous suspension used in the study (7.23 +/-0.7 microgram/ml and 4.82 +/- 0.47 microgram/ml at intervals of 8 and 12 h, respectively) indicated that to maintain serum levels above MIC values for susceptible bacteria a dosage regimen of 20 mg/kg every 12 h is necessary by the intramuscular route.