Preincubation-dependent and long-lasting inhibition of organic anion transporting polypeptide (OATP) and its impact on drug-drug interactions

Preincubation with cyclosporin A (CsA), a potent inhibitor of organic anion transporting polypeptide 1B1 (OATP1B1) and OATP1B3, enhanced its inhibitory effects on these transporters in vitro. A similar effect was observed upon preincubation with some other inhibitors. Removing these from the incubat...

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Bibliographic Details

Published in:	Pharmacology & therapeutics (Oxford) Vol. 177; pp. 67 - 80
Main Authors:	Shitara, Yoshihisa, Sugiyama, Yuichi
Format:	Journal Article
Language:	English
Published:	England 01-09-2017
Subjects:	Animals Cyclosporine - pharmacology Drug Interactions Humans Organic Anion Transporters - antagonists & inhibitors Organic Anion Transporters - metabolism Long-lasting inhibition Time-dependent inhibition Physiologically based pharmacokinetic model Modeling & simulation Hepatic uptake OATP1B1 Drug–drug interactions
Online Access:	Get full text
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