Recent advances in breast cancer immunotherapy: The promising impact of nanomedicines

• Published in: Life sciences (1973) Vol. 271; p. 119110
• Main Authors: Hashemzadeh, Nastaran, Dolatkhah, Mitra, Adibkia, Khosro, Aghanejad, Ayuob, Barzegar-Jalali, Mohammad, Omidi, Yadollah, Barar, Jaleh
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 15-04-2021; Elsevier BV
• Subjects: Antigens; Biomarkers; Biomarkers, Tumor - immunology; Breast cancer; Breast Neoplasms - immunology; Breast Neoplasms - therapy; Cancer; Cancer immunotherapy; Cancer targeting; Cancer therapies; Cancer Vaccines - administration & dosage; Cancer Vaccines - immunology; Chemotherapy; Chimeric antigen receptors; Combined Modality Therapy - methods; Endocrine therapy; Humans; Immune checkpoint inhibitors; Immune system; Immunotherapy; Immunotherapy - methods; Immunotherapy - trends; Lymphocytes; Lymphocytes T; Molecular machines; Nanomedicine - methods; Nanomedicine - trends; Nanomedicines; Patients; Radiation; Solid tumors; Surgery; Tumors; Vaccines; Breast cancer; Immunotherapy; Cancer targeting; Nanomedicines
• ISSN: 0024-3205; 1879-0631
• DOI: 10.1016/j.lfs.2021.119110

Breast cancer (BC) is one of the prevalent cancers among women. Generally, the treatment of BC is mostly based on several prominent strategies, including chemotherapy, surgery, endocrine therapy, molecular targeted therapy, and radiation. Owing to the growing knowledge about the complexity of BC pathobiology, immunotherapy as a promising treatment modality has substantially improved the patients' care in the clinic. Immunotherapy is used to harness the patient's immune system to recognize and battle devious cancer cells. As a novel therapy approach, this emerging strategy targets the key molecular entities of tumor tissue. To achieve maximal therapeutic impacts, the dynamic interplay between cancer and immune cells needs to be fully comprehended. The key molecular machinery of solid tumors can be targeted by nanoscale immunomedicines. While discussing the potential biomarkers involved in the initiation and progression of BC, we aimed to provide comprehensive insights into the immunotherapy and articulate the recent advances in terms of the therapeutic strategies used to control this disease, including immune checkpoint inhibitors, vaccines, chimeric antigen receptor T cells therapy, and nanomedicines.
Advanced breast tumors are often linked to the occurrence of immune system evasion/tolerance, which highlights the desire for the development of novel cancer immunotherapeutics. Nanoscale targeted immunotherapy might be an ultimate therapy in combating breast cancer. [Display omitted]
•Breast cancer therapy is challenging due to the disease relapse and metastasis, even after rigorous chemotherapy.•Targeted drug delivery systems using nanomedicines are an efficient strategy to effectively suppress cancer cells.•Immunotherapy as a novel modality employs the immune system functions to fight cancer.•Tailor-designed nanomedicines can simultaneously deliver various immuno/chemotherapeutic agents to desired site of action.•Nanoscale immuno/chemotherapy approaches provide effective treatment modalities for solid tumors such as breast cancer.