An Old Enemy: Still Nephrotoxic

Tubulointerstitial nephritis (TIN) presents histopathologically as tubulitis and oedema/inflammation and fibrosis, affecting the renal tubules and interstitium with relative sparing of the glomeruli and vasculature. It can be acute or chronic or acute on chronic and has a wide range of etiologies. I...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of the College of Physicians and Surgeons--Pakistan Vol. 31; no. 2; pp. 228 - 231
Main Authors:	Ozalp, Faruk Recep, Karadeniz, Tugba, Alp, Alper
Format:	Journal Article
Language:	English
Published:	Pakistan College of Physicians and Surgeons Pakistan 01-02-2021
Subjects:	Case studies Causes of Complications and side effects Nephritis Nonsteroidal anti-inflammatory drugs Turkey
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Tubulointerstitial nephritis (TIN) presents histopathologically as tubulitis and oedema/inflammation and fibrosis, affecting the renal tubules and interstitium with relative sparing of the glomeruli and vasculature. It can be acute or chronic or acute on chronic and has a wide range of etiologies. In this article, we report a case of a 44-year male who presented with acute TIN, associated with the use of diclofenac at therapeutic doses, that resolved with treatment but later progressed to chronic TIN after the patient resumed diclofenac therapy. The case is discussed in the context of literature regarding the nephrotoxic effects of nonsteroidal anti-inflammatory drugs (NSAIDs). Key Words: Nonsteroidal anti-inflammatory drugs, Acute kidney injury, Tubulointerstitial nephritis.
ISSN:	1022-386X 1681-7168
DOI:	10.29271/JCPSP.2021.02.228