Effect of obesity on fragility fractures, BMD and vitamin D levels in postmenopausal women. Influence of type 2 diabetes mellitus
Aims To see the effects of obesity on risk fracture, bone density (BMD), and vitamin D levels in a group of postmenopausal women, and consider how comorbid type 2 diabetes mellitus (T2DM) modifies them. Methods 679 postmenopausal women were grouped into obese and non-obese. Obese women were grouped...
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| Published in: | Acta diabetologica Vol. 59; no. 9; pp. 1201 - 1208 |
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| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Language: | English |
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Springer Milan
2022
Springer Nature B.V |
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| Abstract | Aims
To see the effects of obesity on risk fracture, bone density (BMD), and vitamin D levels in a group of postmenopausal women, and consider how comorbid type 2 diabetes mellitus (T2DM) modifies them.
Methods
679 postmenopausal women were grouped into obese and non-obese. Obese women were grouped into those with T2DM and those without. 25(OH)-vitamin D, PTH and BMD were measured, and prevalent fragility fractures were gathered.
Results
Obese women had higher prevalence of T2DM, than non-obese women. Levels of 25(OH)-vitamin D were lower and those of PTH higher in obese women, BMD values were higher in obese women. Diabetic-obese women had a higher prevalence of non-vertebral fractures than non-diabetic-obese. Multivariate logistic regression model showed association of fragility fractures with age, total hip BMD, BMI and T2DM. Obese women have higher BMD and lower 25(OH)-vitamin D values (and higher PTH) than non-obese, without diabetes.
Conclusions
T2DM confers an increased risk of non-vertebral fractures in postmenopausal obese women. |
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| AbstractList | AIMSTo see the effects of obesity on risk fracture, bone density (BMD), and vitamin D levels in a group of postmenopausal women, and consider how comorbid type 2 diabetes mellitus (T2DM) modifies them. METHODS679 postmenopausal women were grouped into obese and non-obese. Obese women were grouped into those with T2DM and those without. 25(OH)-vitamin D, PTH and BMD were measured, and prevalent fragility fractures were gathered. RESULTSObese women had higher prevalence of T2DM, than non-obese women. Levels of 25(OH)-vitamin D were lower and those of PTH higher in obese women, BMD values were higher in obese women. Diabetic-obese women had a higher prevalence of non-vertebral fractures than non-diabetic-obese. Multivariate logistic regression model showed association of fragility fractures with age, total hip BMD, BMI and T2DM. Obese women have higher BMD and lower 25(OH)-vitamin D values (and higher PTH) than non-obese, without diabetes. CONCLUSIONST2DM confers an increased risk of non-vertebral fractures in postmenopausal obese women. Aims To see the effects of obesity on risk fracture, bone density (BMD), and vitamin D levels in a group of postmenopausal women, and consider how comorbid type 2 diabetes mellitus (T2DM) modifies them. Methods 679 postmenopausal women were grouped into obese and non-obese. Obese women were grouped into those with T2DM and those without. 25(OH)-vitamin D, PTH and BMD were measured, and prevalent fragility fractures were gathered. Results Obese women had higher prevalence of T2DM, than non-obese women. Levels of 25(OH)-vitamin D were lower and those of PTH higher in obese women, BMD values were higher in obese women. Diabetic-obese women had a higher prevalence of non-vertebral fractures than non-diabetic-obese. Multivariate logistic regression model showed association of fragility fractures with age, total hip BMD, BMI and T2DM. Obese women have higher BMD and lower 25(OH)-vitamin D values (and higher PTH) than non-obese, without diabetes. Conclusions T2DM confers an increased risk of non-vertebral fractures in postmenopausal obese women. |
| Author | Saavedra-Santana, P. Sosa-Henríquez, M. de Tejada-Romero, M. J. Gómez de la Rosa-Fernández, F. Suárez-Ramírez, N. Martín-Martínez, A. del Rosario, F. Martín |
| Author_xml | – sequence: 1 givenname: M. J. Gómez surname: de Tejada-Romero fullname: de Tejada-Romero, M. J. Gómez organization: Research Group On Osteoporosis and Mineral Metabolism, University of Las Palmas de Gran Canaria, Department of Medicine, University of Seville – sequence: 2 givenname: P. surname: Saavedra-Santana fullname: Saavedra-Santana, P. organization: Department of Mathematics, University of Las Palmas de Gran Canaria – sequence: 3 givenname: F. surname: de la Rosa-Fernández fullname: de la Rosa-Fernández, F. organization: Research Group On Osteoporosis and Mineral Metabolism, University of Las Palmas de Gran Canaria – sequence: 4 givenname: N. surname: Suárez-Ramírez fullname: Suárez-Ramírez, N. organization: Research Group On Osteoporosis and Mineral Metabolism, University of Las Palmas de Gran Canaria – sequence: 5 givenname: A. surname: Martín-Martínez fullname: Martín-Martínez, A. organization: Research Group On Osteoporosis and Mineral Metabolism, University of Las Palmas de Gran Canaria, Gynecology and Obstetrics Service, Maternal-Infant Insular University Hospital Complex – sequence: 6 givenname: F. Martín surname: del Rosario fullname: del Rosario, F. Martín organization: Research Group On Osteoporosis and Mineral Metabolism, University of Las Palmas de Gran Canaria – sequence: 7 givenname: M. orcidid: 0000-0001-6845-2933 surname: Sosa-Henríquez fullname: Sosa-Henríquez, M. email: manuel.sosa@ulpgc.es organization: Research Group On Osteoporosis and Mineral Metabolism, University of Las Palmas de Gran Canaria, Bone Metabolic Unit, Maternal-Infant Insular University Hospital Complex |
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| CitedBy_id | crossref_primary_10_1007_s00592_023_02156_2 crossref_primary_10_2147_IJGM_S444318 crossref_primary_10_1007_s11914_024_00867_1 crossref_primary_10_3389_fendo_2023_1289574 |
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| Issue | 9 |
| Keywords | Obesity Osteoporosis Vitamin D Diabetes Mellitus type 2 Fragility fractures |
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Ishii |
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To see the effects of obesity on risk fracture, bone density (BMD), and vitamin D levels in a group of postmenopausal women, and consider how comorbid... AimsTo see the effects of obesity on risk fracture, bone density (BMD), and vitamin D levels in a group of postmenopausal women, and consider how comorbid type... AIMSTo see the effects of obesity on risk fracture, bone density (BMD), and vitamin D levels in a group of postmenopausal women, and consider how comorbid type... |
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| SubjectTerms | Bone mineral density Diabetes Diabetes mellitus (non-insulin dependent) Fractures Internal Medicine Medicine Medicine & Public Health Metabolic Diseases Obesity Original Original Article Osteoporosis Parathyroid hormone Post-menopause Vertebrae Vitamin D |
| Title | Effect of obesity on fragility fractures, BMD and vitamin D levels in postmenopausal women. Influence of type 2 diabetes mellitus |
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