Usefulness of Pancreas Donor Risk Index and Pre-Procurement Pancreas Allocation Suitability Score: Results of the Polish National Study

• Published in: Annals of transplantation Vol. 23; pp. 360 - 363
• Main Authors: Śmigielska, Kaja, Skrzypek, Paweł, Czerwiński, Jarosław, Michalak, Grzegorz, Durlik, Marek, Grochowiecki, Tadeusz, Nazarewski, Sławomir, Szmidt, Jacek, Ziaja, Jacek, Król, Robert, Cierpka, Lech, Lisik, Wojciech, Kosieradzki, Maciej
• Format: Journal Article
• Language: English
• Published: United States International Scientific Literature, Inc 25-05-2018
• Subjects: Adult; Donor Selection - methods; Female; Graft Survival; Health Surveys; Humans; Male; Original Paper; Pancreas Transplantation - adverse effects; Pancreas Transplantation - mortality; Poland; Risk Factors; Tissue and Organ Procurement; Tissue Donors; Transplant Recipients; Treatment Outcome; Young Adult
• ISSN: 1425-9524; 2329-0358
• DOI: 10.12659/AOT.909654

BACKGROUND Pre-procurement pancreas suitability score (P-PASS) and pancreas donor risk (PDRI) index are scoring systems believed to predict suitability of pancreatic grafts. Most European countries and the United States apply PDRI, while Poltransplant keeps using P-PASS: more than 16 points raises a red flag for graft use. Recent data discourage use of PDRI to predict pancreas graft survival. The aim of the present study was to assess PDRI and P-PASS as predictors of transplanted pancreas survival in a Polish population. MATERIAL AND METHODS From February 1998 to September 2015, 407 pancreas transplantations were performed in Poland: 370 (90.9%) simultaneous pancreas-kidney transplantation and 37 (9.1%) pancreas transplantation alone or pancreas after kidney. The endpoint was death-uncensored 12-month graft survival with satisfactory glycemic control without insulin. RESULTS Average P-PASS was 15.9±2.66 and PDRI was 0.96±0.37. Recipients who survived 12 months with good graft function had an average P-PASS score of 15.7 and PDRI of 0.95. Recipients with death-uncensored graft loss had a mean P-PASS of 16.4 and PDRI of 0.99. Univariate analysis revealed donor age, body mass index (BMI), and P-PASS to be significant risk factors for 1-year pancreas graft survival. CONCLUSIONS P-PASS, but not PDRI, is a reliable tool to predict pancreas graft survival in the Polish population.