α-Phenyl- N- tert-butyl nitrone (PBN) derivatives: Synthesis and protective action against microvascular damages induced by ischemia/reperfusion

Protective effects against microvascular damages in ischemia/reperfusion in the ‘hamster cheek pouch’ assay. Nitrones 4– 7, structurally related to PBN ( 1), were prepared by reaction of the corresponding aromatic aldehydes with N- tert-butyl hydroxylamine. The protective effects of these nitrones a...

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Bibliographic Details
Published in:	Bioorganic & medicinal chemistry Vol. 15; no. 10; pp. 3572 - 3578
Main Authors:	Kim, Sothea, de A. Vilela, Guilherme V.M., Bouajila, Jalloul, Dias, Ayres G., Cyrino, Fatima Z.G.A., Bouskela, Eliete, Costa, Paulo R.R., Nepveu, Françoise
Format:	Journal Article
Language:	English
Published:	Oxford Elsevier Ltd 15-05-2007 Elsevier Science
Subjects:	Animals Biological and medical sciences Capillaries - drug effects Capillaries - pathology Cardiovascular system Chromatography, High Pressure Liquid Cricetinae Cyclic N-Oxides - chemical synthesis Cyclic N-Oxides - pharmacology Electron Spin Resonance Spectroscopy Fluorescent Dyes Indicators and Reagents Ischemia/reperfusion Male Medical sciences Mesocricetus Miscellaneous Mouth Mucosa - blood supply Mouth Mucosa - pathology PBN derivatives Pharmacology. Drug treatments Protective action against microvascular damages Regional Blood Flow - drug effects Reperfusion Injury - pathology Reperfusion Injury - prevention & control Spectrophotometry, Ultraviolet Structure-Activity Relationship PBN derivatives Protective action against microvascular damages Ischemia/reperfusion Ischemia reperfusion Nitrone Rodentia Oral administration Cardiovascular disease Partition coefficient Physicochemical properties activity relationship Prevention Vascular disease Vertebrata Chemotherapy Mammalia Treatment Structure activity relation Animal Aromatic compound Chemical synthesis Hamster Lipophilicity
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