Nitric Oxide Synthase Inhibition by Pentacycloundecane Conjugates of Aminoguanidine and Tryptamine

This paper describes the synthesis and in‐vitro activity of pentacycloundecane‐conjugated aminoguanidine and tryptamine analogues on nitric oxide synthase (NOS) using rat brain homogenate. Both aminoguanidine and tryptamine‐derived NOS inhibitors show selectivity towards the inducible and neuronal i...

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Bibliographic Details
Published in:	Archiv der Pharmazie (Weinheim) Vol. 342; no. 2; pp. 73 - 79
Main Authors:	Wilkes, Dennis K., de Vries, Armand, Oliver, Douglas W., Malan, Sarel F.
Format:	Journal Article
Language:	English
Published:	Weinheim WILEY-VCH Verlag 01-02-2009 WILEY‐VCH Verlag
Subjects:	Aminoguanidine Animals Brain - drug effects Brain - enzymology Bridged-Ring Compounds - chemical synthesis Bridged-Ring Compounds - chemistry Bridged-Ring Compounds - pharmacology Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Guanidines - chemical synthesis Guanidines - chemistry Guanidines - pharmacology In Vitro Techniques Inhibitory Concentration 50 Male Molecular Structure Nitric oxide synthase Nitric Oxide Synthase - antagonists & inhibitors Pentacycloundecane Rats Rats, Sprague-Dawley Tryptamine Tryptamines - chemical synthesis Tryptamines - chemistry Tryptamines - pharmacology
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