Non-functional Fas ligand increases the formation of cartilage early in the endochondral bone induction by rhBMP-2

It has previously been shown that mice with a defect in Fas ligand-mediated apoptosis have an enhancement of ectopic bone formation. We investigated the expression of bone-related markers - alkaline phosphatase, collagen, bone sialoprotein, osteocalcin, osteopontin, and bone morphogenetic proteins (...

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Bibliographic Details
Published in:	Life sciences (1973) Vol. 74; no. 1; pp. 13 - 28
Main Authors:	Katavic, V, Grcevic, D, Lukic, I K, Vucenik, V, Kovacic, N, Kalajzic, I, Marusic, A
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Inc 21-11-2003
Subjects:	Animals Apoptosis Blotting, Northern Bone Bone Development - genetics Bone Morphogenetic Protein 2 Bone morphogenetic proteins Bone Morphogenetic Proteins - pharmacology Cartilage - drug effects Cartilage - growth & development Fas ligand Fas Ligand Protein Gene knockout Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Membrane Glycoproteins - physiology Mice Mice, Inbred C57BL Osteoinduction Phenotype Point Mutation Polymerase Chain Reaction Recombinant Proteins - pharmacology Transforming Growth Factor beta Fas ligand Phenotype Gene knockout Osteoinduction Bone morphogenetic proteins Mice Bone Apoptosis
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