Isotretinoin in dermatology

Isotretinoin in dermatology

BACKGROUND: Isotretinoin (13- cis retinoic acid) revolutionized the treatment of acne. Since the early 1980s patients suffering from severe forms of acne have been treated effectively, with less residual cosmetic or psychological damage. OBJECTIVE: The aim of this article is to provide a wide review...

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Bibliographic Details
Published in:The Journal of dermatological treatment Vol. 11; no. 4; pp. 219 - 240
Main Authors: Amichai, B, Grunwald, M H
Format: Journal Article
Language:English
Published: Oslo Informa UK Ltd 2000
Taylor & Francis
Subjects:
Biological and medical sciences
Isotretinoin Side Effects Therapy
Medical sciences
Pharmacology. Drug treatments
Skin, nail, hair, dermoskeleton
Human
Cell proliferation
Skin disease
Drug combination
Secretion
Toxicity
Acne
Antiinflammatory agent
Retinoid
Epidermis
Review
Cell differentiation
Biological activity
Sebaceous gland
Immunomodulator
Chemotherapy
Treatment
Drug interaction
Isotretinoin
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Summary:BACKGROUND: Isotretinoin (13- cis retinoic acid) revolutionized the treatment of acne. Since the early 1980s patients suffering from severe forms of acne have been treated effectively, with less residual cosmetic or psychological damage. OBJECTIVE: The aim of this article is to provide a wide review of isotretinoin, including its clinical applications in dermatology, side effects and drug interactions. DISCUSSION: Isotretinoin affects epidermal cell growth and differentiation as well as sebaceous gland activity, and exhibits immunomodulatory and antiinflammatory properties, which are important in the treatment of a wide range of other cutaneous diseases - mainly disorders of keratinization and also in proliferative diseases. (J Dermatol Treat (2000) 11: 219-240)
ISSN:0954-6634
1471-1753
DOI:10.1080/095466300750134214