Persistent and Selective Deficiency of CD4+ T Cell Immunity to Cytomegalovirus in Immunocompetent Young Children

Healthy young children who acquire CMV have prolonged viral shedding into the urine and saliva, but whether this is attributable to limitations in viral-specific immune responses has not been explored. In this study, we found that otherwise immunocompetent young children after recent primary CMV inf...

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Bibliographic Details
Published in:	The Journal of immunology (1950) Vol. 172; no. 5; pp. 3260 - 3267
Main Authors:	Tu, Wenwei, Chen, Sharon, Sharp, Margaret, Dekker, Corry, Manganello, Anne Marie, Tongson, Eileen C, Maecker, Holden T, Holmes, Tyson H, Wang, Zhaoti, Kemble, George, Adler, Stuart, Arvin, Ann, Lewis, David B
Format:	Journal Article
Language:	English
Published:	United States Am Assoc Immnol 01-03-2004
Subjects:	Adult Age Factors CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism CD4-Positive T-Lymphocytes - virology CD40 Ligand - biosynthesis CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - virology Child, Preschool Cytomegalovirus - immunology Cytomegalovirus Infections - immunology Cytomegalovirus Infections - virology Female Humans Immunity, Cellular Immunologic Memory Infant Interferon-gamma - biosynthesis Interleukin-2 - antagonists & inhibitors Interleukin-2 - biosynthesis Lymphocyte Count Male Middle Aged Receptors, CCR7 Receptors, Chemokine - biosynthesis T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism T-Lymphocyte Subsets - virology Th1 Cells - immunology Th1 Cells - metabolism Th1 Cells - virology Virus Shedding - immunology
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