Fcγ receptor II (CD32) on malignant B cells influences modulation induced by anti-CD19 monoclonal antibody

Antigenic modulation is one of many factors determining the effectiveness of monoclonal antibody (MoAb)-mediated therapy. To select the isotype of a CD19 MoAb most suitable for radioimmunotherapy of patients with B-cell malignancies, we studied the influence of MoAb isotype on modulation, after bind...

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Bibliographic Details
Published in:	Blood Vol. 83; no. 6; pp. 1632 - 1639
Main Authors:	VERVOORDELDONK, S. F, MERLE, P. A, VAN LEEUWEN, E. F, VAN DER SHOOT, C.E, VON DEM BORNE, A. E. G. K, SLAPER-CORTENBACH, I. C. M
Format:	Journal Article
Language:	English
Published:	Washington, DC The Americain Society of Hematology 15-03-1994
Subjects:	Antibodies, Monoclonal - immunology Antigens, CD - physiology Antigens, CD19 Antigens, Differentiation, B-Lymphocyte - physiology Biological and medical sciences Burkitt Lymphoma - immunology Calcium - metabolism Hematologic and hematopoietic diseases Humans Immunoglobulin Class Switching Immunoglobulin G - immunology Leukemia, Lymphocytic, Chronic, B-Cell - immunology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma, B-Cell - immunology Medical sciences Receptors, IgG - analysis Receptors, IgG - physiology Tumor Cells, Cultured Human Malignant hemopathy B-Lymphocyte Monoclonal antibody Antigenic modulation
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